Threonate

Vitamin B 12 [ TREATMENT ]; FOLATE [ PREVENTION ]; OTHER [ SUPPLEMENTATION ];

• EnBrace HR ® is indicated in the TREATMENT of vitamin deficiency - specifically vitamin B 12 deficiency, and the PREVENTION of vitamin B 12 -cofactor deficiency, l-methylfolate. Requirements of vitamin B 9 and/or vitamin B 12 in excess of normal due to pregnancy can usually be met with oral supplementation.

​: The recommended dosage is one (1) capsule daily, preferably on an empty stomach. Dosage may be adjusted by a healthcare provider based on individual patient needs. As a general rule reticulocyte plasma count, folate and vitamin B 12 status must be obtained prior to treatment. Do not exceed the recommended dose. Call your medical practitioner about side effects. You may report side effects by calling (866) 280-5961.

Mild transient diarrhea, polycythemia vera, itching, transitory exanthema, feeling of swelling of entire body may occur with administration of vitamin B 12 . Allergic sensitization has been reported following both oral and parenteral administration of folic acid.

1. 1Abnormal Dreams114%
2. 2Agranulocytosis114%
3. 3Anxiety Disorder114%
4. 4Catheter Site Erythema114%
5. 5Catheter Site Irritation114%
6. 6Clostridium Difficile Infection114%
7. 7Cognitive Disorder114%
8. 8Drug Ineffective114%
9. 9Dysarthria114%
10. 10Foot Operation114%
11. 11Hallucination114%
12. 12Infusion Site Pain114%
13. 13Infusion Site Urticaria114%
14. 14Injection Site Pain114%
15. 15Insomnia114%

The 10 most recently updated of 12 ClinicalTrials.gov registrations naming Threonate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• UCLA Magnesium Formulation Athlete Study
  Not yet recruiting · Interventional · 150 enrolled · University of California, Los Angeles
  NCT07640685updated 2026-06-11
• Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty
  Recruiting · Phase 4 · Interventional · 64 enrolled · University of Miami
  NCT06902285updated 2026-04-23
• Supplement Combination on Stress and Sleep
  Completed · Interventional · 115 enrolled · University of South Carolina
  NCT06889584updated 2026-02-11
• Effects of Magnesium L-Threonate on Sleep, Recovery, and Athletic Performance in Collegiate Athletes
  Active not recruiting · Interventional · 100 enrolled · University of California, Los Angeles
  NCT07015047updated 2025-10-15
• Effect of MMFS-202-302 on Cognitive Enhancement in Schizophrenia
  Completed · Phase 2 · Interventional · 60 enrolled · Northwestern University
  NCT02237235updated 2025-06-22
• Magnesium-L-Threonate Improves Menopausal Symptoms
  Not yet recruiting · Interventional · 50 enrolled · Guangdong Provincial People's Hospital
  NCT06959745updated 2025-05-07
• Magnesium Supplementation in People With XMEN Syndrome
  Completed · Phase 1 · Phase 2 · Interventional · 8 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT02496676updated 2022-03-02
• Magnesium L-Threonate for the Enhancement of Learning and Memory in People With Dementia
  Completed · Interventional · 17 enrolled · Stanford University
  NCT02210286updated 2021-02-02
• Efficacy and Safety of MMFS in Early AD
  Completed · Phase 2 · Interventional · 10 enrolled · Neurocentria, Inc.
  NCT03531684updated 2020-09-09
• Comparison of MMFS Dosages in Older Adults
  Completed · Phase 2 · Interventional · 9 enrolled · Neurocentria, Inc.
  NCT03601169updated 2020-09-09

Frequently asked questions

How does Threonate work?

Vitamin B 12 [ TREATMENT ]; FOLATE [ PREVENTION ]; OTHER [ SUPPLEMENTATION ];

What is Threonate used for?

According to FDA labeling, Threonate carries indications including: EnBrace HR ® is indicated in the TREATMENT of vitamin deficiency - specifically vitamin B 12 deficiency, and the PREVENTION of vitamin B 12 -cofactor deficiency, l-methylfolate. Requirements of vitamin B 9 and/or vitamin B 12 in excess of normal due to pregnancy can usually be met with oral supplementation.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.