Triethanolamine

• INDICATION AND USAGE Salicor™ is indicated for the temporary relief of minor aches and pains of muscles and joints associated with: arthritis, simple backache, muscle strains and sprains, bruises, bursitis, and dysmenorrhea. Salicor™ provides a localized analgesic effect directly at the site of pain, offering convenience and sustained relief compared to cream formulations.

For adults 18 years and older: • Clean and dry the affected area • Locate the tear notch on the edge of the pouch. Tear open at the notch or carefully cut open the pouch with scissors, taking care not to cut the system inside • Remove the transparent release liner before applying Salicor™ to the skin • Apply one Salicor™ to the affected area of pain and leave it in place for 8 to 12 hours • Apply only one Salicor™ at a time • If pain persists, the used Salicor™ may be replaced with a new one for up to 8 to 12 more hours • Always remove and properly dispose of the used Salicor™ before applying a new one • Salicor™ may be cut into smaller sizes with scissors prior to removing the release liner • Safely discard the used Salicor™ (whole or cut pieces) where children and pets cannot access it • Wash hands with soap and water after applying or removing Salicor™ Visual Guide provided below: These highlights do not include all the information needed to use Salicor™ safely and effectively. See full prescribing information for Salicor™ dosing

General If irritation or a burning sensation occurs during application, wash the product off your skin and do not reapply until the irritation subsides. When Salicor™ is used concomitantly with other products containing local anesthetic agents, the amount absorbed from all formulations must be considered. Stop use and ask a doctor if • Condition worsens • Symptoms persist for more than 7 days, or symptoms return within a few days after discontinuing use • Redness is present • Irritation develops Hepatic Disease Patients with severe hepatic disease are at greater risk of developing toxic blood concentrations of triethanolamine salicylate because of their inability to metabolize triethanolamine salicylate normally. Allergic Reactions Although rare, allergic reactions to oral or external triethanolamine salicylate may occur. Seek emergency medical help if you experience hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, as these may indicate a serious allergic reaction. Non-intact Skin Although not tested, application to broken or inflamed skin may result in higher blood concentrations of triethanolamine salicylate from increased absorption. Salicor™ is only recommended for use on intact skin. External Heat Sources Placement of external heat sources, such as heating pads or electric blankets, over Salicor™ is not recommended, as this has not been evaluated and may increase plasma triethanolamine salicylate levels.

Pregnancy Before taking NSAIDs, tell your healthcare provider about all of your medical conditions, including if you are pregnant or plan to become pregnant. Taking NSAIDs at about 20 weeks of pregnancy or later may harm your unborn baby. If you need to take NSAIDs for more than 2 days when you are between 20 and 30 weeks of pregnancy, your healthcare provider may need to monitor the amount of fluid in your womb around your baby. You should not take NSAIDs after about 30 weeks of pregnancy. Pregnancy Category B. Salicor™ has not been studied in pregnancy.

Metabolism

Absorption Following external administration of Salicor™ to healthy volunteers, no detectable levels of salicylic acid were found in the serum, indicating low systemic absorption. This minimal absorption is advantageous as it reduces the risk of systemic side effects commonly associated with oral salicylates.

Salicor™ is intended for external use only. While systemic toxicity is unlikely with proper use, accidental ingestion or excessive application may lead to salicylate toxicity. Symptoms of overdose may include: nausea and vomiting, tinnitus (ringing in the ears), dizziness and confusion, rapid breathing (hyperventilation), sweating, headache, and fever. In severe cases, overdose may lead to more serious symptoms such as: seizures, hallucinations, respiratory distress, kidney failure, and metabolic acidosis. If overdose is suspected, discontinue use immediately and seek medical attention. Treatment is supportive and symptomatic. Healthcare professionals may need to monitor fluid and electrolyte balance, correct acid-base disturbances, and manage any complications.

1. 1Agitation150%
2. 2Asthenia150%
3. 3Choking Sensation150%
4. 4Cognitive Disorder150%
5. 5Delusion150%
6. 6Depressed Mood150%
7. 7Dysuria150%
8. 8Fall150%
9. 9Fatigue150%
10. 10Hallucination150%
11. 11Micturition Urgency150%
12. 12Moaning150%
13. 13Paranoia150%
14. 14Parkinson^s Disease150%
15. 15Pollakiuria150%

The 10 most recently updated of 20 ClinicalTrials.gov registrations naming Triethanolamine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Clinical Study on the Prevention and Treatment of Radiation Vaginitis With Triethanolamine Cream
  Not yet recruiting · Phase 4 · Interventional · 238 enrolled · Fujian Cancer Hospital
  NCT07492654updated 2026-03-25
• Efficacy of Coconut Gel Compared to Corticosteroid Gel in the Management of Oral Lichen Planus
  Not yet recruiting · Phase 4 · Interventional · 30 enrolled · Ain Shams University
  NCT07100145updated 2025-08-06
• Efficacy of Fullerene in Preventing Radiation Dermatitis in Patients With Head and Neck Cancer .
  Completed · Interventional · 132 enrolled · West China Hospital
  NCT06484166updated 2025-06-04
• Clinical Observation of Drug Retention Enema in Preventing Acute Radiation-induced Rectal Injury
  Recruiting · Interventional · 200 enrolled · Fujian Cancer Hospital
  NCT06325982updated 2024-06-05
• Topical Composition Therapy for the Treatment of Cutaneous Mastocytosis
  Terminated · Phase 2 · Interventional · 1 enrolled · Joseph Butterfield
  NCT04846348updated 2024-04-25
• Assessing the Efficacy of a Hydrogen Peroxide Gel for Oral Wound Healing and Oral Hygiene
  Completed · Interventional · 54 enrolled · National and Kapodistrian University of Athens
  NCT06370260updated 2024-04-17
• Development of a Protective Cream Against Radiodermatitis Caused by Radiotherapy.
  Unknown · Interventional · 5 enrolled · Antonio J. Conde Moreno
  NCT05886673updated 2023-10-05
• Topical Piroxicam vs Soulagel in the Treatment of Acute Extremity Pain After Emergency Department Discharge
  Completed · Phase 2 · Phase 3 · Interventional · 1,525 enrolled · University of Monastir
  NCT05054023updated 2022-06-21
• Effect of Melatonin on Palatal Wound Healing (Randomized Controlled Clinical Trial)
  Unknown · Phase 2 · Interventional · 26 enrolled · Salma Nabil
  NCT05122130updated 2022-01-26
• Clinical Adhesion Study Between ZTlido 1.8% and Three Over-the-counter External Analgesic Lidocaine-containing Patches
  Completed · Phase 1 · Interventional · 24 enrolled · Scilex Pharmaceuticals, Inc.
  NCT05106400updated 2021-11-03

Frequently asked questions

What is Triethanolamine used for?

According to FDA labeling, Triethanolamine carries indications including: INDICATION AND USAGE Salicor™ is indicated for the temporary relief of minor aches and pains of muscles and joints associated with: arthritis, simple backache, muscle strains and sprains, bruises, bursitis, and dysmenorrhea. Salicor™ provides a localized analgesic effect directly at the site of pain, offering convenience and sustained relief compared to cream formulations.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Triethanolamine?

Triethanolamine is classified as Other cicatrizants.