Valine
US-FDASourced from openFDA
GET
/api/v1/drug/valineIndications
Sourced from openFDA- Take 15 minutes before meals
Dosage & administration
Sourced from openFDADIRECTIONS Adults and children 12 years and older 20 drops in a little water, 2 times per day Children between 12 years and 6 years of age 10 drops in a little water, 2 times per day Children under 6 years 5 drops in a glass of water, 2 times per day
Warnings & precautions
Sourced from openFDAStop use and ask doctor if symptoms persist more than 5 days. If pregnant or breast-feeding ask a health professional before use. Keep out of reach of children . In case of overdose, get medical help or contact a Poison Control Center right away. Contains ethyl alcohol 30%
Approval history
Sourced from openFDA- Jul 20, 1984NDANDA019018B Braun
- Aug 23, 1984NDANDA018931Baxter Hlthcare
- Sep 6, 1985NDANDA019398Otsuka Icu Medcl
- Oct 17, 1986NDANDA019492Otsuka Icu Medcl
- Dec 19, 1991NDANDA020041Otsuka Icu Medcl
- Dec 19, 1991NDANDA020015Otsuka Icu Medcl
- Mar 26, 1997NDANDA020678Baxter Hlthcare
- Sep 29, 1997NDANDA020734Baxter Hlthcare
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
719 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Parenteral Nutrition Associated Liver Disease507.0%
- 2Nausea456.3%
- 3Pyrexia425.8%
- 4Vomiting405.6%
- 5Chills354.9%
- 6Death354.9%
- 7Dyspnoea304.2%
- 8No Adverse Event304.2%
- 9Diarrhoea283.9%
- 10Asthenia253.5%
- 11Palpitations233.2%
- 12Pneumonia223.1%
- 13Pruritus223.1%
- 14Chest Discomfort202.8%
- 15Anaemia182.5%
Literature
Recent PubMed references pinned to Valine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Comparative effects of sacubitril/valsartan versus enalapril on QRS duration and cardiac function in heart failure patients undergoing left bundle branch area pacing.Pakistan journal of pharmaceutical sciences · 2026 · Wang R, Hao C, Fang Z, et al.PMID 42262190DOI 10.36721/PJPS.2026.39.8.216.1
- Resolution of Hand, Foot, and Mouth Disease With Valacyclovir.Journal of drugs in dermatology : JDD · 2026 · Nusrat F, Neubauer Z, Yang S, et al.PMID 42235036DOI 10.36849/JDD.9394
- Efficacy of Sacubitril/Valsartan in Treating Hemodialysis Patients with Reduced Ejection Fraction Heart Failure: A Retrospective Study.Iranian journal of kidney diseases · 2025 · Guo Y, Li W, Diao Z, et al.PMID 42234894
- Drug-Drug Interaction of Chiglitazar with Empagliflozin, Atorvastatin, and Valsartan: An Open-Label, Single-Center, Self-Control, 3-Period Study.Drug design, development and therapy · 2026 · Sheng L, Li X, Yu J, et al.PMID 42148367DOI 10.2147/DDDT.S588573
- Formulation, Optimization and In vivo Evaluation of Freeze-Dried Nanocapsules for Enhancing the Oral Delivery of Valsartan.AAPS PharmSciTech · 2026 · Abdelhameed AH, Farghaly U, Fathalla ZM, et al.PMID 42128997DOI 10.1208/s12249-026-03443-1
- Cardiorenal protective effects of dapagliflozin combined with valsartan in patients with type 2 diabetes mellitus and hypertension: a retrospective cohort study.Frontiers in endocrinology · 2026 · Zhou Z, Gong KPMID 42109733DOI 10.3389/fendo.2026.1804226
- DL-norvaline attenuated HFD-induced metabolic inflammation and dysfunction with integrated pharmacokinetic, biodistribution, and safety evaluation.European journal of pharmacology · 2026 · Li X, Wang X, Lü X, et al.PMID 42105997DOI 10.1016/j.ejphar.2026.178943
- Measuring What Matters: Further Validation for the Tardive Dyskinesia Impact Scale, a Novel Patient-Reported Outcome Measure in Valbenazine Clinical Trials.The Journal of clinical psychiatry · 2026 · Bron M, Mathias SD, Stull DE, et al.PMID 42095693DOI 10.4088/JCP.25nr16047
Clinical trials
The 10 most recently updated of 436 ClinicalTrials.gov registrations naming Valine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage PD PatientsRecruiting · Interventional · 120 enrolled · Taipei Medical UniversityNCT07619560updated 2026-06-02
- ARNI Combined With SGLT2 Inhibitors on Functional Mitral Regurgitation RemodelingCompleted · Interventional · 180 enrolled · Rehab WeridaNCT07379788updated 2026-06-02
- SMART Diets for MASLDRecruiting · Phase 2 · Interventional · 102 enrolled · Michigan State UniversityNCT07459504updated 2026-06-01
- Effect of Branched-Chain Amino Acid Supplementation on Myopia ProgressionActive not recruiting · Interventional · 108 enrolled · Zhongda HospitalNCT07585877updated 2026-05-14
- A Study of Becotatug Vedotin (MRG003) Combined With Epirubicin as Neoadjuvant Therapy for EGFR-Positive, Unresectable Recurrent Sinonasal Adenoid Cystic CarcinomaRecruiting · Phase 2 · Interventional · 40 enrolled · Eye & ENT Hospital of Fudan UniversityNCT07522879updated 2026-05-12
- Effects of VALsartan On atRIAl Mitral RegurgitationNot yet recruiting · Phase 2 · Phase 3 · Interventional · 50 enrolled · Jonathan BeaudoinNCT07539298updated 2026-05-12
- Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)Not yet recruiting · Phase 4 · Interventional · 64 enrolled · Baylor Research InstituteNCT07547878updated 2026-05-08
- Repurposing Valsartan May Protect Against Pulmonary HypertensionRecruiting · Phase 2 · Interventional · 60 enrolled · University of WashingtonNCT06053580updated 2026-05-04
- [177Lu]-NeoB in Patients With Advanced Solid Tumors and With [68Ga]-neoB Lesion UptakeCompleted · Phase 1 · Phase 2 · Interventional · 35 enrolled · Advanced Accelerator ApplicationsNCT03872778updated 2026-04-30
- Effectiveness of Valsartan Alone vs Combination Therapy in Hypertensive Heart DiseaseCompleted · Phase 1 · Interventional · 118 enrolled · Shaikh Zayed Hospital, LahoreNCT07544888updated 2026-04-22
Frequently asked questions
- What is Valine used for?
- According to FDA labeling, Valine carries indications including: Take 15 minutes before meals. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What are the brand names for Valine?
- Valine is marketed under brand names including Aminosyn 10%, Sulfite-Free, Aminosyn 3.5 % M, Sulfite Free, Aminosyn 8.5 % with Electrolytes, Sulfite-Free, Aminosyn 8.5%, Sulfite-Free, Aminosyn II 10 %, Aminosyn II 15%, Aminosyn II 8.5 % with Electrolytes, Sulfite-Free, Aminosyn II 8.5 %, Sulfite-Free.
Note. Data for
valine is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.