pharmacopeia
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/api/v1/drug/xenon

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

Indications

Sourced from openFDA
  • Xenon Xe 133 Gas has been shown to be valuable for diagnostic inhalation studies for the evaluation of pulmonary function, for imaging the lungs and may also be applied to assessment of cerebral blood flow.

Contraindications

Sourced from openFDA
  • None known.contraindicated

Dosage & administration

Sourced from openFDA

Xenon Xe 133 Gas is administered by inhalation from a closed respirator system or spirometer. The final patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration. The recommended activity range employed for inhalation by the average patient (70 kg) is: Pulmonary function including imaging: 74 to 1110 megabecquerels (2 to 30 millicuries) Cerebral blood flow: 370 to 1110 megabecquerels (10 to 30 millicuries) This may be administered as a bolus into the tubing near the patient's mouthpiece or mask after the completion of a tidal exhalation, or by rebreathing for a period of approximately 5 minutes of the Xenon Xe 133 gas in equilibrium with the air contained in the closed system at concentrations of the radionuclide that may vary from 37 to 222 megabecquerels (1.0 to 6.0 millicuries) per liter.

Warnings & precautions

Sourced from openFDA

Xenon Xe 133 Gas delivery systems, i.e., respirators or spirometers, and associated tubing assemblies must be leakproof to avoid loss of radioactivity into the laboratory environs not specifically protected by exhaust systems. Xenon Xe 133 Gas adheres to some plastics and rubber and should not be allowed to stand in tubing or respirator containers. Loss of radioactivity due to such adherence may render the study nondiagnostic.

Adverse reactions

Sourced from openFDA

Adverse reactions specifically attributable to Xenon Xe 133 Gas have not been reported.

Use in specific populations

Sourced from openFDA

Pregnancy Animal reproduction studies have not been conducted with Xenon Xe 133 Gas. It is also not known whether Xenon Xe 133 Gas can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Xenon Xe 133 Gas should be given to a pregnant woman only if clearly needed. Ideally, all examinations that use radiopharmaceuticals, especially those elective in nature, of a woman of childbearing capability should be performed during the first few (approximately 10) days following the onset of menses.

Approval history

Sourced from openFDA
  • Oct 10, 1974NDANDA017284Shine
  • Mar 9, 1982NDANDA018327Curium
  • Dec 23, 2022NDANDA214375Polarean

FAERS reports

View JSON
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
13 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Occupational Exposure To Product431%
  2. 2Nasal Discomfort215%
  3. 3Throat Irritation215%
  4. 4Urticaria215%
  5. 5Accidental Exposure17.7%
  6. 6Accidental Exposure To Product17.7%
  7. 7Alanine Aminotransferase Decreased17.7%
  8. 8Beta 2 Microglobulin Increased17.7%
  9. 9Blood Alkaline Phosphatase Increased17.7%
  10. 10Blood Bilirubin Decreased17.7%
  11. 11Blood Cholinesterase Decreased17.7%
  12. 12Blood Creatine Phosphokinase Decreased17.7%
  13. 13Blood Phosphorus Increased17.7%
  14. 14Blood Potassium Decreased17.7%
  15. 15Cardiac Failure17.7%

Literature

View JSON

Recent PubMed references pinned to Xenon as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 147 ClinicalTrials.gov registrations naming Xenon as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Frequently asked questions

How does Xenon work?
Mechanism-of-action class: Unknown Cellular or Molecular Interaction.
What is Xenon used for?
According to FDA labeling, Xenon carries indications including: Xenon Xe 133 Gas has been shown to be valuable for diagnostic inhalation studies for the evaluation of pulmonary function, for imaging the lungs and may also be applied to assessment of cerebral blood flow.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Xenon?
Xenon is classified as Other diagnostic agents, Other general anesthetics, Unknown Cellular or Molecular Interaction, Decreased Organized Electrical Activity.
What are the contraindications for Xenon?
Xenon labeling lists contraindications including: None known.. Always consult the full prescribing information and a clinician.
Note. Data for xenon is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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