Xylometazoline

Mechanism-of-action classes: Adrenergic alpha1-Agonists; Adrenergic alpha2-Agonists; Adrenergic beta1-Agonists; Adrenergic beta2-Agonists.

• Adults and children 7 years and older: Spray into the nose 3 times a day

for nasal use

■ When using this product Stop use and ask a doctor if nervousness, diziness, or sleepness occur. Pain, nasal congestion or cough gets worse or lasts more than 7 days. fever gets worse or lasts more than 3 days New symtoms occur. keep out of reach of children. In case of overdose, get medical help or contact a poison contral center right away. If pregnant or breast-feeding, ask a health professional before use.

1. 1Nausea6913%
2. 2Sepsis5510%
3. 3Dyspnoea5310.0%
4. 4Vomiting529.8%
5. 5Abdominal Distension519.6%
6. 6Constipation509.4%
7. 7Fatigue499.2%
8. 8Condition Aggravated489.0%
9. 9Covid-19448.3%
10. 10Off Label Use448.3%
11. 11Stress448.3%
12. 12Abdominal Pain438.1%
13. 13Ascites438.1%
14. 14Somnolence438.1%
15. 15Headache397.3%

The 10 most recently updated of 37 ClinicalTrials.gov registrations naming Xylometazoline as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Blocking Sphenopalatine Ganglion by Intranasal Lidocaine Spray in Partial Turbinectomy Surgeries
  Recruiting · Phase 3 · Interventional · 50 enrolled · Ain Shams University
  NCT07299630updated 2026-06-09
• CLINICAL STUDY TO IDENTIFY BIOMARKERS FOR TUMOR SPREAD THROUGH AIR SPACES STATUS
  Not yet recruiting · Observational · 140 enrolled · Universidade Nova de Lisboa
  NCT07630246updated 2026-06-05
• Observational Study That Will Analyse the Spread and Stratification of Lung Cancer Risk Using Artificial Intelligence
  Not yet recruiting · Observational · 1,500 enrolled · AstraZeneca
  NCT07617636updated 2026-06-01
• Oxytocin's Effects on Emotional Processing and Its Acting Routes
  Recruiting · Interventional · 120 enrolled · University of Electronic Science and Technology of China
  NCT07425938updated 2026-02-23
• A Study Comparing Proponent Solution - Nasal Spray (PSNS) With Salt Water for Treating Nasal Congestion Symptoms in Adults With Rebound Nasal Congestion While Weaning From Nasal Decongestant Sprays
  Completed · Interventional · 194 enrolled · Pharma Nordic AS
  NCT06817967updated 2025-04-25
• A Study Comparing Degu Insulin Liraglutide Injection With Premixed Insulin on the Prognosis of Diabetes Mellitus
  Enrolling by invitation · Phase 4 · Interventional · 170 enrolled · Beijing Tsinghua Chang Gung Hospital
  NCT06925334updated 2025-04-13
• Get Out of Your Head 2.0: Evaluation of an Online Prevention Campaign and Updated Website for Men
  Not yet recruiting · Interventional · 288 enrolled · University Ghent
  NCT06810674updated 2025-02-05
• Adrenaline Nasal Pack vs Xylometazoline Nasal Drops During Nasotracheal Intubation
  Recruiting · Phase 2 · Phase 3 · Interventional · 70 enrolled · Shaheed Mohtarma Benazir Bhutto Institue of Trauma
  NCT06801522updated 2025-01-30
• Cocaine, Lidocaine/xylometazoline and Saline for Nasal Analgesia
  Completed · Phase 3 · Interventional · 16 enrolled · Rigshospitalet, Denmark
  NCT06443255updated 2024-09-27
• LiveSpo Navax® Supports the Treatment of Acute Rhinosinusitis and Otitis Media
  Completed · Interventional · 175 enrolled · Anabio R&D
  NCT05804123updated 2024-08-22

Frequently asked questions

How does Xylometazoline work?

Mechanism-of-action classes: Adrenergic alpha1-Agonists; Adrenergic alpha2-Agonists; Adrenergic beta1-Agonists; Adrenergic beta2-Agonists.

What is Xylometazoline used for?

According to FDA labeling, Xylometazoline carries indications including: Adults and children 7 years and older: Spray into the nose 3 times a day. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Xylometazoline?

Xylometazoline is classified as Sympathomimetics, combinations excl. corticosteroids, Sympathomimetics, plain, Sympathomimetics used as decongestants, Adrenergic alpha1-Agonists, Adrenergic alpha2-Agonists, Adrenergic beta1-Agonists, Adrenergic beta2-Agonists, Vasoconstriction.