Zirconium
US-FDASourced from openFDA
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/api/v1/drug/zirconiumIndications
Sourced from openFDA- Uses reduces underarm wetness 24 hour protection
Dosage & administration
Sourced from openFDADirections apply to underarms only
Warnings & precautions
Sourced from openFDAFor external use only Do not use on broken skin Ask a doctor before use if you have kidney disease Stop use if rash or irritation occurs Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
Approval history
Sourced from openFDA- May 18, 2018NDANDA207078Astrazeneca
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
3,489 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Death1,01229%
- 2Blood Potassium Increased1775.1%
- 3Diarrhoea1484.2%
- 4Hyperkalaemia1363.9%
- 5Off Label Use1143.3%
- 6Constipation1133.2%
- 7Cardiac Failure842.4%
- 8Nausea832.4%
- 9Acute Kidney Injury762.2%
- 10Renal Failure762.2%
- 11Drug Ineffective742.1%
- 12Vomiting722.1%
- 13Hypokalaemia712.0%
- 14Chronic Kidney Disease692.0%
- 15Dyspnoea671.9%
Literature
Recent PubMed references pinned to Zirconium as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- In Vitro Evaluation of the Fracture Resistance of CAD/CAM-Manufactured Zirconia Crowns on Primary Teeth: A Comparison of Two Different Cement Types and Gap Widths.Nigerian journal of clinical practice · 2026 · Güngör İlhan GM, Erdoğan Y, Özbey İpek H, et al.PMID 42241200DOI 10.4103/njcp.njcp_380_25
- Effect of Polishing on Surface Roughness and Bacterial Adhesion of Prefabricated Zirconia and Fiber Pediatric Crowns: An In vitro Study.Nigerian journal of clinical practice · 2026 · Anlar MN, Çiftçi ZZ, Çoban AY, et al.PMID 42241196DOI 10.4103/njcp.njcp_699_25
- Dual-ligand Zr-based metal-organic framework probe with turn-on fluorescent response for dual-channel live cell imaging of phosphate and glutathione.Mikrochimica acta · 2026 · Wei X, Wang H, Feng X, et al.PMID 42237033DOI 10.1007/s00604-026-08104-5
- Microbial evaluation of zirconia and titanium implants in the anterior mandibula: a randomized controlled clinical trial.Scientific reports · 2026 · Kniha K, Scholz K, Kohnert E, et al.PMID 42230722DOI 10.1038/s41598-026-54915-0
- Microleakage in 5Y-TZP zirconia ceramic crowns and the influence of deep margin elevation: a laboratory investigation.Clinical oral investigations · 2026 · Jansen L, Kern M, Wille S, et al.PMID 42230405DOI 10.1007/s00784-026-06950-4
- Improving Orthodontic Bracket Adhesion to Monolithic Zirconia: Pretreatment Protocols Across Different Zirconia Types.The journal of adhesive dentistry · 2026 · Kuipers N, Kern M, Wille S, et al.PMID 42210806DOI 10.3290/j.jad.c_2668
- Biaxial strength under fatigue of 4YSZ: Surface treatment and resin cement viscosity effects.PloS one · 2026 · Teixeira KF, Cocco F, Soares PM, et al.PMID 42207817DOI 10.1371/journal.pone.0349754
- Zirconia versus Titanium Implants: 1-year Prosthetic Outcome of Screw-Retained Single Crowns in a Randomized Clinical Trial.Clinical implant dentistry and related research · 2026 · Balmer M, Fischer A, Kühl S, et al.PMID 42206453DOI 10.1111/cid.70160
Clinical trials
The 10 most recently updated of 122 ClinicalTrials.gov registrations naming Zirconium as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Safety and Dosimetry of a New Radiotracer to Detect Misfolded SOD1 Associated With Amyotrophic Lateral SclerosisCompleted · Phase 1 · Interventional · 8 enrolled · Université de SherbrookeNCT05974579updated 2026-06-01
- VITALIZE.Use and Effectiveness of Sodium Zirconium Cyclosilicate (LokelmaTM) in the Real-world Setting in SpainCompleted · Observational · 232 enrolled · AstraZenecaNCT06635499updated 2026-05-22
- An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With HyperkalaemiaRecruiting · Phase 3 · Interventional · 140 enrolled · AstraZenecaNCT03813407updated 2026-05-15
- Study Assessing PET Imaging With Zirconium-labelled Girentuximab in Patients With HCC, BTC or NENRecruiting · Interventional · 60 enrolled · Nantes University HospitalNCT06735560updated 2026-05-13
- OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosili-cate in Heart Failure -Extension (OPRA-HF Extension)Not yet recruiting · Phase 2 · Interventional · 110 enrolled · Sahlgrenska University HospitalNCT07576257updated 2026-05-08
- (89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell CarcinomaRecruiting · Phase 1 · Interventional · 60 enrolled · Eben RosenthalNCT05747625updated 2026-05-08
- Lokelma for RAAS Maximisation in CKD & Heart Failure.Completed · Phase 3 · Interventional · 112 enrolled · St George's, University of LondonNCT05004363updated 2026-04-27
- Comparison of Potassium Binders in the ERTerminated · Phase 4 · Interventional · 37 enrolled · University of California, IrvineNCT04585542updated 2026-04-22
- Novel Dental Cements (ALBO-MPCA) in Patients With CariesCompleted · Interventional · 20 enrolled · Albos d.o.o. BeogradNCT07507136updated 2026-04-02
- First-in-human Study of Interferon-y PET Imaging to Assess Response to ImmunotherapyRecruiting · Phase 1 · Interventional · 6 enrolled · Nerissa T. ViolaNCT06439914updated 2026-03-11
Frequently asked questions
- What is Zirconium used for?
- According to FDA labeling, Zirconium carries indications including: Uses reduces underarm wetness 24 hour protection. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
Note. Data for
zirconium is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.