Acute Hepatic Failure
9 drugs302 FAERS reportsMedDRA PT
GET
/api/v1/reaction/acute-hepatic-failureReference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.
DefinitionNLM MeSH D017114
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
Source: U.S. National Library of Medicine — MeSH (Liver Failure, Acute)
Drugs reporting Acute Hepatic Failure (9)
Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.
- 1Methane120%
- 2Piperine111%
- 3Fomepizole105.4%
- 4Adenosine Triphosphate13.8%
- 5Triphosphate13.8%
- 6Nalbuphine62.7%
- 7Lusutrombopag12.6%
- 8Pyrazinamide2352.6%
- 9Propylthiouracil462.3%
Related reactions
Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.
- Aortic Valve Stenosis2 shared · 0.22
- Neuromyopathy2 shared · 0.20
- Systemic Candida2 shared · 0.20
- Apathy2 shared · 0.18
- Aplastic Anaemia2 shared · 0.17
- Blood Culture Positive2 shared · 0.17
- Encephalopathy4 shared · 0.13
- Hypocalcaemia2 shared · 0.13
- Acute Respiratory Distress Syndrome2 shared · 0.12
- Mental Status Changes2 shared · 0.12
Literature
Recent PubMed references pinned to Liver Failure, Acute as a MeSH major topic. About the reaction term itself — not about any specific drug.
- Role of Gram-Negative Bacterial Infections in Acute-On-Chronic Liver Failure.Liver international : official journal of the International Association for the Study of the Liver · 2026 · Cadoli C, Müller V, Welsch C, et al.PMID 42188459DOI 10.1111/liv.70710
- Multi-Omics Identified Factor V Leiden as a Novel Predictor of 90-Day Mortality in Artificial Liver-Supported ACLF: A Translational Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · Zhao W, Ruan H, Li L, et al.PMID 42186733DOI 10.1096/fj.202504139RRR
- Midodrine versus placebo in patients with acute-on-chronic liver failure with ascites-A randomized trial (MIDAS trial).Hepatology communications · 2026 · Kulkarni AV, Venishetty S, Prasanna S, et al.PMID 42172504DOI 10.1097/HC9.0000000000000966
- Hypoxia-preconditioned bone marrow mesenchymal stem cells alleviate acute liver failure in association with the VEGF/c-Met pathway.Molecular biology reports · 2026 · Lan MM, Shi RZ, Li ZY, et al.PMID 42165955DOI 10.1007/s11033-026-11883-y
- Plasmapheresis in Low Body Weight Infant With Acute Liver Failure.Journal of clinical apheresis · 2026 · Kimberger K, Blacklock-Lumb C, Armitage E, et al.PMID 42152244DOI 10.1002/jca.70134
- Emergency ABO-Incompatible Living-Donor Liver Transplantation for Acute Liver Failure due to Intentional Iron Poisoning.Pediatric transplantation · 2026 · Wada S, Uebayashi EY, Okamoto T, et al.PMID 42136191DOI 10.1111/petr.70339
Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.