Piperine

• For the temporary relief of stomach irritation, minor joint pain or swelling, or sneezing due to sensitivity to phenolic compounds found in foods or other products.*

DIRECTIONS Place drops under tongue 30 minutes before/after meals. Adults and children 12 years and over: Take 10 drops up to 3 times per day. Consult a physician for use in children under 12 years of age.

In case of overdose, get medical help or contact a poison control center right away. Keep out of the reach of children. If pregnant or breastfeeding, ask a healthcare professional before use.

1. 1Acute Hepatic Failure111%
2. 2Aura111%
3. 3Biliary Dilatation111%
4. 4Bladder Cyst111%
5. 5Carbohydrate Antigen 125 Increased111%
6. 6Cataract111%
7. 7Cephalhaematoma111%
8. 8Condition Aggravated111%
9. 9Disease Progression111%
10. 10Diverticulum Intestinal111%
11. 11Drug Abuse111%
12. 12Drug Ineffective111%
13. 13Drug Interaction111%
14. 14Encephalopathy111%
15. 15Erectile Dysfunction111%

The 10 most recently updated of 35 ClinicalTrials.gov registrations naming Piperine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer
  Completed · Phase 2 · Interventional · 30 enrolled · University of Rochester
  NCT04731844updated 2026-05-12
• Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms
  Recruiting · Phase 2 · Interventional · 30 enrolled · University of Southern California
  NCT06063486updated 2026-03-27
• Curcumin, Resveratrol, and Stinging Nettle as Treatments for GWI
  Active not recruiting · Interventional · 390 enrolled · University of Alabama at Birmingham
  NCT05377242updated 2025-11-26
• Curcumin-Piperine Supplementation in STEMI - SPICE STEMI Trial
  Completed · Interventional · 50 enrolled · Universitas Diponegoro
  NCT07149961updated 2025-09-02
• Methylglyoxal (MGO) Lowering Cocktail to Reduce Appetite in Obese Individuals
  Withdrawn · Phase 1 · Phase 2 · Interventional · 0 enrolled · University of California, San Francisco
  NCT05083546updated 2025-08-29
• Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity
  Completed · Early phase 1 · Interventional · 13 enrolled · Hoskinson Health and Wellness Clinic
  NCT06242535updated 2025-06-10
• Curcumin Supplementation in Cervical Cancer
  Recruiting · Interventional · 30 enrolled · National Institute of Cancerología
  NCT06080841updated 2025-05-25
• Study of High-Dose Resveratrol in Patients With Stable Ischemic Heart Disease
  Completed · Interventional · 70 enrolled · S.LAB (SOLOWAYS)
  NCT06914934updated 2025-04-23
• Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients With Cancer
  Completed · Phase 1 · Interventional · 9 enrolled · Mayo Clinic
  NCT02598726updated 2025-04-22
• Efficacy and Safety of a Nutraceutical Supplement With Standardized Botanicals in Peri-menopausal and Menopausal Women With Thinning Hair
  Completed · Interventional · 70 enrolled · Ablon Skin Institute Research Center
  NCT04048031updated 2025-04-06

Frequently asked questions

What is Piperine used for?

According to FDA labeling, Piperine carries indications including: For the temporary relief of stomach irritation, minor joint pain or swelling, or sneezing due to sensitivity to phenolic compounds found in foods or other products.*. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.