Injection Site Reaction
23 drugs35,219 FAERS reportsMedDRA PT
GET
/api/v1/reaction/injection-site-reactionReference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.
DefinitionNLM MeSH D000075662
Adverse reactions that occur initially at the site of injection or infusion. Milder type is confined to a local allergic flare reaction. A more severe reaction is caused by extravasation of VESICANTS from the blood vessel at the site of injection and can cause damage to the surrounding tissue. In tumor flare reaction symptoms involve well beyond the injection site such as an increase in the tumor size and tumor markers levels, bone pain, and HYPERCALCEMIA.
Source: U.S. National Library of Medicine — MeSH (Injection Site Reaction)
Drugs reporting Injection Site Reaction (23)
Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.
- 1Pozelimab125%
- 2Pegvaliase88511%
- 3Diatrizoate5711%
- 4Naltrexone4,41611%
- 5Motixafortide89.0%
- 6Asfotase Alfa7027.5%
- 7Glatiramer3,5865.8%
- 8Rilonacept545.6%
- 9Ixekizumab1,7734.9%
- 10Peginterferon Beta-1a5784.5%
- 11Interferon Beta-1b8394.4%
- 12Nitrogen43.8%
- 13Etanercept20,8863.5%
- 14Lurbinectedin343.3%
- 15Fremanezumab2962.7%
- 16Inclisiran2012.7%
- 17Meprobamate332.6%
- 18Donidalorsen42.5%
- 19Galcanezumab7202.4%
- 20Tralokinumab1011.8%
- 21Lebrikizumab241.7%
- 22Lenacapavir71.7%
- 23Ganirelix101.6%
Related reactions
Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.
- Injection Site Pruritus12 shared · 0.33
- Injection Site Swelling11 shared · 0.31
- Injection Site Erythema15 shared · 0.31
- Injection Site Mass7 shared · 0.21
- Injection Site Bruising8 shared · 0.19
- Injection Site Rash4 shared · 0.15
- Injection Site Pain18 shared · 0.12
- Injection Site Haemorrhage3 shared · 0.09
- Multiple Sclerosis3 shared · 0.08
- Conjunctivitis2 shared · 0.07
Literature
Recent PubMed references pinned to Injection Site Reaction as a MeSH major topic. About the reaction term itself — not about any specific drug.
- Efficacy and Safety of Extracorporeal Shock Wave Therapy and 1064 nm Nd:YAG Laser in Managing Nodules and Edema Following Cosmetic Injections: A Case Series and Systematic Literature Review.Journal of cosmetic dermatology · 2026 · Wang J, Gu J, Wang Z, et al.PMID 42087490DOI 10.1111/jocd.70883
- A Retrospective Case Series Reporting the Safety of a Polyvinyl Alcohol (PVA) Composite Filler for Facial Augmentation.Journal of cosmetic dermatology · 2026 · Wang WT, Ya ZM, Pu CL, et al.PMID 41913323DOI 10.1111/jocd.70823
- Mycobacterium lentiflavum complicating insulin injection sites.BMJ case reports · 2026 · Anjaneyan G, Joseph ST, Pavithran PV, et al.PMID 41633756DOI 10.1136/bcr-2025-266835
- Characterizing Safety Outcomes of a Dermal Filler: Injection Site and Timing Insights from the Maude Database.Journal of drugs in dermatology : JDD · 2026 · Spivak M, Auerbach E, Eisenreich E, et al.PMID 41493258DOI 10.36849/JDD.9491
- Injection-site and dermatologic reactions associated with glucagon-like peptide-1 receptor agonists: Insights from meta-analysis of randomised controlled trials and real-world evidence.Diabetes, obesity & metabolism · 2026 · Taj S, Zuber M, Rashid M, et al.PMID 41395692DOI 10.1111/dom.70382
- Injection-site pain after long-acting rilpivirine: No association with tempering time in a prospective observational study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · Sabogal S, Martínez-Burgoa T, Valls-Carbó A, et al.PMID 41390014DOI 10.1016/j.ijid.2025.108310
Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.