Lactic Acidosis
12 drugs20,494 FAERS reportsMedDRA PT
GET
/api/v1/reaction/lactic-acidosisReference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.
DefinitionNLM MeSH D000140
Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
Source: U.S. National Library of Medicine — MeSH (Acidosis, Lactic)
Drugs reporting Lactic Acidosis (12)
Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.
- 1Fomepizole115.9%
- 2Repaglinide3655.0%
- 3Eravacycline115.0%
- 4Metformin18,8134.3%
- 5Fosamprenavir53.8%
- 6Methylene Blue603.5%
- 7Linezolid9863.4%
- 8Trandolapril643.1%
- 9Acarbose1072.8%
- 10Angiotensin Ii82.8%
- 11Nateglinide372.8%
- 12Nimodipine272.5%
Related reactions
Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.
- Cerebral Ischaemia2 shared · 0.17
- Shock3 shared · 0.13
- Intentional Overdose4 shared · 0.11
- Hypoglycaemia5 shared · 0.11
- Coagulopathy2 shared · 0.08
- Hyperkalaemia2 shared · 0.07
- Blood Bilirubin Increased2 shared · 0.06
- Serotonin Syndrome2 shared · 0.06
- Encephalopathy2 shared · 0.06
- Blood Glucose Increased4 shared · 0.06
Literature
Recent PubMed references pinned to Acidosis, Lactic as a MeSH major topic. About the reaction term itself — not about any specific drug.
- Diagnosing Metformin Intoxication with High-Resolution Platelet Respirometry: A Case Report.International journal of molecular sciences · 2026 · Sobotka O, Staňková P, Fortunato J, et al.PMID 42196606DOI 10.3390/ijms27104631
- Lactate abnormalities during intravenous linezolid therapy in hospitalized children: a brief report.European journal of pediatrics · 2026 · Ozsumbul TI, Demir OO, Aykac K, et al.PMID 42105018DOI 10.1007/s00431-026-07064-5
- Linezolid-Associated Triad of Acute Pancreatitis, Lactic Acidosis, and Hypoglycemia: A Rare Case Report and Literature Review.The American journal of case reports · 2026 · Makin MA, Subki AH, Bokhary MI, et al.PMID 41843536DOI 10.12659/AJCR.950688
- Incidence of phosphate abnormalities after cardiac surgery and their association with lactic acidosis: A cohort study from the Multicenter Perioperative Outcomes Group.Journal of clinical anesthesia · 2026 · Steck DT, Silliman WL, Li R, et al.PMID 41785615DOI 10.1016/j.jclinane.2026.112157
- Diffuse large B-cell lymphoma combined with hyperlactatemia presents high mortality: case report and literature review.MedScience · 2026 · Jiao Y, Zhang J, Yan X, et al.PMID 41733881DOI 10.1007/s11684-025-1199-2
- Clinical differences between metformin-associated lactic acidosis and metformin-unrelated lactic acidosis: A descriptive study.The American journal of emergency medicine · 2026 · Okazaki Y, Inoue F, Ichiba T, et al.PMID 41619701DOI 10.1016/j.ajem.2026.01.027
Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.