Serotonin Syndrome
22 drugs3,453 FAERS reportsMedDRA PT
GET
/api/v1/reaction/serotonin-syndromeReference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.
DefinitionNLM MeSH D020230
An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
Source: U.S. National Library of Medicine — MeSH (Serotonin Syndrome)
Drugs reporting Serotonin Syndrome (22)
Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.
- 1Octopamine1100%
- 2Methylene Blue46427%
- 3Serotonin8017%
- 4Isocarboxazid68.3%
- 5Tranylcypromine615.5%
- 6Neostigmine825.3%
- 7Tiagabine44.9%
- 8Desflurane744.4%
- 9Cyproheptadine1844.3%
- 10Hetastarch63.7%
- 11Fluvoxamine813.5%
- 12Sevoflurane2523.2%
- 13Linezolid9043.1%
- 14Nitazoxanide103.0%
- 15Methamphetamine323.0%
- 16Succinylcholine1123.0%
- 17Tedizolid212.7%
- 18Estazolam502.6%
- 19Cisatracurium552.6%
- 20Lasmiditan282.5%
- 21Rocuronium2242.0%
- 22Propofol7222.0%
Related reactions
Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.
- Hyperthermia Malignant5 shared · 0.19
- Bronchospasm4 shared · 0.13
- Anaphylactic Shock6 shared · 0.12
- Rhabdomyolysis5 shared · 0.12
- Bradycardia9 shared · 0.11
- Hypoxia6 shared · 0.11
- Anaesthetic Complication Neurological2 shared · 0.09
- Metabolic Acidosis3 shared · 0.09
- Hypertensive Crisis2 shared · 0.08
- Cardiac Arrest9 shared · 0.08
Literature
Recent PubMed references pinned to Serotonin Syndrome as a MeSH major topic. About the reaction term itself — not about any specific drug.
- An evaluation of linezolid-associated serotonin toxicity in combination with serotonergic agents at a community teaching hospital.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2026 · Donaldson C, Cerenzio J, Andrade J, et al.PMID 41549325DOI 10.1093/ajhp/zxaf358
- Carisoprodol poisoning with serotonin toxicity.BMJ case reports · 2025 · O'Flynn CS, Singh S, Tan G, et al.PMID 41360496DOI 10.1136/bcr-2025-269513
- Time Course of Serum Dextromethorphan Concentrations in a Case of Serotonin Syndrome After Massive Overdose.The American journal of case reports · 2025 · Yamada S, Taniguchi H, Terayama T, et al.PMID 41348645DOI 10.12659/AJCR.949204
- Evaluation of clinical findings in predicting the development of serotonin syndrome: can the Hunter's criteria be used in children?Postgraduate medicine · 2025 · Özcan AS, Yaradilmiş RM, Akkaya B, et al.PMID 41269012DOI 10.1080/00325481.2025.2592356
- Fatal outcome of severe serotonin syndrome and acute respiratory distress syndrome after self-poisoning with paroxetine: a case report.Journal of medical case reports · 2025 · Pütz SM, Hüser C, Onur OA, et al.PMID 41084074DOI 10.1186/s13256-025-05602-7
- Polypharmacy-induced serotonin syndrome revealing underlying neurocognitive impairment and cervical myelopathy.BMJ case reports · 2025 · Shah J, Parsons A, Pathuri S, et al.PMID 40998535DOI 10.1136/bcr-2025-267753
Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.