Adenine

Mechanism-of-action class: Biological Macromolecular Activity.

• For the temporary relief of fatigue, nausea, or sleeplessness due to sensitivity to phenolic compounds found in foods or other products.*ICD-10: R11.2

DIRECTIONS Place drops under tongue 30 minutes before/after meals. Adults and children 12 years and over: Take 10 drops up to 3 times per day. Consult a physician for use in children under 12 years of age.

In case of overdose, get medical help or contact a poison control center right away. Keep out of the reach of children. If pregnant or breastfeeding, ask a healthcare professional before use.

1. 1Drug Ineffective47.1%
2. 2Insomnia47.1%
3. 3Malaise47.1%
4. 4Neutropenia47.1%
5. 5Neutrophil Count Decreased47.1%
6. 6Pyrexia47.1%
7. 7Rash47.1%
8. 8Somnolence47.1%
9. 9White Blood Cell Count Decreased47.1%
10. 10Abdominal Pain35.4%
11. 11Nausea35.4%
12. 12Salivary Hypersecretion35.4%
13. 13Antipsychotic Drug Level Decreased23.6%
14. 14Blood Creatine Phosphokinase Increased23.6%
15. 15Candida Infection23.6%

Recent PubMed references pinned to Adenine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Cost-effectiveness analysis of ibrutinib plus venetoclax for relapsed or refractory mantle cell lymphoma in China and the United States.
  Frontiers in public health · 2026 · He J, Liu X, Yang Q, et al.
  PMID 42254648DOI 10.3389/fpubh.2026.1817037
• Neutrophil extracellular traps in the animal model of adenine-induced chronic kidney disease.
  PloS one · 2026 · Gaál Kovalčíková A, Forraiová G, Korotushak N, et al.
  PMID 42247428DOI 10.1371/journal.pone.0350004
• 6mA DNA methylation dynamics during chloroplast development in Agave angustifolia Haw.
  Planta · 2026 · Decle-Carrasco S, Andrade-Marcial M, López-Huicochea EA, et al.
  PMID 42236585DOI 10.1007/s00425-026-05038-3
• CaCRF6, A Cytokinin Response Factor, Confers Cold Tolerance in Capsicum.
  Physiologia plantarum · 2026 · Zhang T, Cao T, Yang H, et al.
  PMID 42219287DOI 10.1111/ppl.70945
• Comparative safety of B/F/TAF versus other antiretroviral therapy regimens for treatment-experienced people with HIV-1: a systematic literature review and network meta-analysis.
  Journal of comparative effectiveness research · 2026 · Curteis T, Eddowes LA, Karlsson A, et al.
  PMID 42206806DOI 10.57264/cer-2026-0013
• Cytokinin histidine kinase receptors regulate multiple aspects of rice growth and development.
  Plant physiology · 2026 · Shouse EM, Aragón-Raygoza A, Tallerday EJ, et al.
  PMID 42172676DOI 10.1093/plphys/kiag215
• An adenine-based molecular rotor as a fluorescent nucleobase with high brightness.
  Organic & biomolecular chemistry · 2026 · Pushkarevskaya AA, Kamzeeva PN, Belyaev ES, et al.
  PMID 42149062DOI 10.1039/d6ob00486e
• Prevotella bivia Influences Antiretroviral Pharmacokinetics and Viral Replication in an Ex Vivo Vaginal Tissue Model.
  Clinical and translational science · 2026 · Lantz AM, Collins LB, Hirsch EB, et al.
  PMID 42148717DOI 10.1111/cts.70597

The 10 most recently updated of 1,149 ClinicalTrials.gov registrations naming Adenine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Early Metabolic Effects of Antiretroviral Drugs in Healthy volUnteers: a Phase 2 Randomized Study
  Recruiting · Phase 2 · Interventional · 120 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT05652478updated 2026-06-12
• A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments
  Recruiting · Phase 4 · Interventional · 350 enrolled · Gilead Sciences
  NCT06337032updated 2026-06-10
• Comparative Trial Between Ainuovirine(ANV)/Lamivudine(3TC)/Tenofovir(TDF) and Efavirenz(EFV)/Lamivudine/Tenofovir Regimens
  Not yet recruiting · Phase 4 · Interventional · 60 enrolled · Shanghai Public Health Clinical Center
  NCT07631897updated 2026-06-08
• A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)
  Recruiting · Phase 3 · Interventional · 4,390 enrolled · Merck Sharp & Dohme LLC
  NCT07044297updated 2026-06-08
• Biktarvy in Treatment-Naïve Late Presenters With HIV-1 Infection
  Completed · Phase 4 · Interventional · 202 enrolled · Peking Union Medical College Hospital
  NCT04296695updated 2026-06-05
• Inhibition of HBV Replication and Biological Reversal of Cirrhosis (F3-F4) and HCC by Flavonoids
  Completed · Phase 4 · Interventional · 134 enrolled · Trieu, Nguyen Thi, M.D.
  NCT07084948updated 2026-06-05
• Research On Nicotinamide Riboside Supplement Support in MDS (ROSS Trial)
  Recruiting · Phase 2 · Interventional · 10 enrolled · University of Colorado, Denver
  NCT07579429updated 2026-06-03
• Dolutegravir Versus Dolutegravir in Combination With Tenofovir for the Treatment of HTLV-1 Infection
  Recruiting · Phase 2 · Interventional · 146 enrolled · Carlos Brites
  NCT07555431updated 2026-06-02
• Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations
  Completed · Phase 3 · Interventional · 5,949 enrolled · National Cancer Institute (NCI)
  NCT02883049updated 2026-06-02
• A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)
  Recruiting · Phase 3 · Interventional · 4,580 enrolled · Merck Sharp & Dohme LLC
  NCT07071623updated 2026-06-01

Frequently asked questions

How does Adenine work?

Mechanism-of-action class: Biological Macromolecular Activity.

What is Adenine used for?

According to FDA labeling, Adenine carries indications including: For the temporary relief of fatigue, nausea, or sleeplessness due to sensitivity to phenolic compounds found in foods or other products.*. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Adenine?

Adenine is classified as Biological Macromolecular Activity, Metabolic Activity Alteration.