Amyl Nitrite
GET
/api/v1/drug/amyl-nitriteMechanism of action
Sourced from openFDAMechanism-of-action class: Nitric Oxide Donors.
Indications
Sourced from openFDA- Uses: See symptoms on front panel.
Dosage & administration
Sourced from openFDAAdults and children: At the onset of symptoms, dissolve 5 pellets under the tongue 3 times a day until symptoms are relieved or as directed by a doctor.
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
60 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Drug Interaction1932%
- 2Methaemoglobinaemia1118%
- 3Drug Abuse1017%
- 4Genital Hypoaesthesia813%
- 5Tinnitus813%
- 6Syncope712%
- 7Agitation610%
- 8Dysstasia58.3%
- 9Logorrhoea58.3%
- 10Muscular Weakness58.3%
- 11Skin Discolouration58.3%
- 12Somnolence58.3%
- 13Tachyphrenia58.3%
- 14Toxicity To Various Agents46.7%
- 15Presyncope35.0%
Literature
Recent PubMed references pinned to Amyl Nitrite as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- A phase 1, first-in-human, open label, single ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of stabilized isoamyl nitrite nasal spray in healthy adult participants.The Journal of pharmacology and experimental therapeutics · 2025 · Cassie D, Mirceta M, Tian J, et al.PMID 40382810DOI 10.1016/j.jpet.2025.103584
- Seizures and severe methaemoglobinaemia following accidental ingestion of amyl nitrite.BMJ case reports · 2024 · Timmons PPMID 38806397DOI 10.1136/bcr-2023-259384
- Effect of Mavacamten on Hypertrophic Cardiomyopathy Patients With Left Ventricular Outflow Tract Obstruction Provoked Only Postexercise or With Amyl Nitrite.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2024 · Roehl K, Suppah M, Geske J, et al.PMID 38266966DOI 10.1016/j.echo.2024.01.009
- Perinasal Dermatitis to Amyl Nitrites ("Poppers' Dermatitis").Journal of cutaneous medicine and surgery · 2022 · Leducq S, Samimi MPMID 34192943DOI 10.1177/12034754211027853
- Unilateral contact dermatitis of the breast caused by amyl nitrites (poppers).Annales de dermatologie et de venereologie · 2021 · Kluger N, Frances PPMID 33558035DOI 10.1016/j.annder.2020.08.057
- Diagnostic differences in the pharmacologic response to cholecystokinin and amyl nitrite in patients with absent contractility vs type I Achalasia.Neurogastroenterology and motility · 2020 · Babaei A, Shad S, Massey BT, et al.PMID 32350982DOI 10.1111/nmo.13857
- Man With Cyanosis and Altered Mental Status.Annals of emergency medicine · 2020 · Runkle A, Block J, Haydar S, et al.PMID 31866026DOI 10.1016/j.annemergmed.2019.06.029
- Symmetrical pruriginous nasal rash.Cutis · 2019 · Navarrete-Dechent C, Uribe PPMID 31675409
Clinical trials
The 2 most recently updated of 2 ClinicalTrials.gov registrations naming Amyl Nitrite as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic CardiomyopathyWithdrawn · Interventional · 0 enrolled · Mayo ClinicNCT04905173updated 2022-01-11
- Diagnostic Utility of Amyl Nitrite in Patients With Suspected Achalasia Undergoing High Resolution Esophageal Manometry (HREM)Withdrawn · Interventional · 0 enrolled · Johns Hopkins UniversityNCT02428959updated 2019-09-30
Frequently asked questions
- How does Amyl Nitrite work?
- Mechanism-of-action class: Nitric Oxide Donors.
- What is Amyl Nitrite used for?
- According to FDA labeling, Amyl Nitrite carries indications including: Uses: See symptoms on front panel.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Amyl Nitrite?
- Amyl Nitrite is classified as Antidotes, Nitric Oxide Donors, Arterial Vasodilation, Increased Nitric Oxide Activity, Vascular Smooth Muscle Tone Alteration, Venous Vasodilation.
Note. Data for
amyl-nitrite is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.