Carnitine

Mechanism-of-action class: Biological Macromolecular Activity.

• Aids in mobilization of fat deposits and cellulite.† †Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated.

DIRECTIONS: Adults: 2 to 3 sprays orally, three times daily. Children under twelve one half adult dosage. Do not take within 15 minutes of consuming food, beverage or brushing teeth. Consult a physician for use in children under 12 years of age.

Professional Use Only If pregnant or breast-feeding, ask a health professional before use. In case of overdose, get medical help or contact a Poison Control Center right away. If condition worsens, seek medical attention. KEEP OUT OF REACH OF CHILDREN Do not use if tamper evident seal is broken or missing. Store in a cool place after opening

1. 1Fatigue375.8%
2. 2Nausea365.7%
3. 3Dizziness274.3%
4. 4Headache253.9%
5. 5Diarrhoea243.8%
6. 6Asthenia233.6%
7. 7Drug Ineffective233.6%
8. 8Insomnia233.6%
9. 9Dyspnoea223.5%
10. 10Pain223.5%
11. 11Vomiting223.5%
12. 12Malaise213.3%
13. 13Arthralgia203.2%
14. 14Somnolence203.2%
15. 15Death182.8%

Recent PubMed references pinned to Carnitine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• SLC16A9-Mediated Carnitine Uptake Enhances Radiotherapy Resistance in Colorectal Cancer via Lipid Metabolic Reprogramming.
  Comprehensive Physiology · 2026 · Wang M, Tang J, Wen X, et al.
  PMID 42271166DOI 10.1002/cph4.70184
• Simultaneous determination of acylcarnitines, fatty acids, and amino acids by 3-nitrophenylhydrazine derivatization and ultra-high performance liquid chromatography/tandem mass spectrometry.
  Journal of chromatography. A · 2026 · Ardalani H, Dannarm SR, Spégel P, et al.
  PMID 42166804DOI 10.1016/j.chroma.2026.467105
• Structural Diversity and Analytical Characterization of Acylhomocarnitines.
  Journal of proteome research · 2026 · Weinberg J, Crandall WJ, Jarrell ZR, et al.
  PMID 42127330DOI 10.1021/acs.jproteome.5c01255
• Feeds supplemented with L-carnitine and varying oil sources improve the Rhamdia quelen thawed sperm redox balance and sperm movement.
  Cryobiology · 2026 · Baumgartner LA, Cardoso SU, da Silva WA, et al.
  PMID 42105529DOI 10.1016/j.cryobiol.2026.105638
• Acylcarnitines and prediction of renal function decline in type 2 diabetes.
  BMJ open diabetes research & care · 2026 · Trischitta V, Fontana A, Shah H, et al.
  PMID 42091203DOI 10.1136/bmjdrc-2025-005748
• Vincristine-Induced Craniofacial Skeletal Teratogenicity in Foetal Rabbits: Multimodal Morphometric Assessment and Partial Protection by L-Carnitine.
  Anatomia, histologia, embryologia · 2026 · El Latif AIA, El Sharaby AA, Hagras EM, et al.
  PMID 42080665DOI 10.1111/ahe.70120
• [Gender differences in acylcarnitine metabolism among patients with depression disorder].
  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025 · Lei H, Liu T, Lu Y, et al.
  PMID 42032986DOI 10.11817/j.issn.1672-7347.2025.250548
• IGF-1 attenuates high fat diet-elicited cardiomyopathy via arachidylcarnitine-dependent suppression of ferroptosis and mitochondrial dysfunction.
  European journal of pharmacology · 2026 · Wang L, Shen M, Abudureyimu M, et al.
  PMID 41990905DOI 10.1016/j.ejphar.2026.178873

The 10 most recently updated of 304 ClinicalTrials.gov registrations naming Carnitine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Evaluation of the Clinical Impact of Adjunctive L-carnitine Therapy in Critically Ill Hepatic Patients Admitted to Intensive Care Unit
  Not yet recruiting · Phase 4 · Interventional · 58 enrolled · Beni-Suef University
  NCT07642076updated 2026-06-11
• Long-Chain Fatty Acid Oxidation Disorders In-Clinic Disease Monitoring Program
  Active not recruiting · Observational · 150 enrolled · Ultragenyx Pharmaceutical Inc
  NCT04632953updated 2026-06-03
• Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma
  Active not recruiting · Phase 3 · Interventional · 440 enrolled · Children's Oncology Group
  NCT05602194updated 2026-06-02
• Matching Perfusion and Metabolic Activity in HFpEF
  Recruiting · Phase 2 · Interventional · 53 enrolled · University of Pennsylvania
  NCT04913805updated 2026-06-02
• DMSO Dual-Route Therapy for Refractory Tinnitus in Long-COVID and Post-COVID-19 Vaccine Injury
  Enrolling by invitation · Phase 2 · Interventional · 20 enrolled · Leading Edge Clinic
  NCT07567274updated 2026-05-13
• Efficacy of L-carnitine Versus Placebo in the Treatment of Fatigue in Multiple Sclerosis
  Completed · Phase 3 · Interventional · 59 enrolled · University Hospital, Bordeaux
  NCT01149525updated 2026-05-12
• Optimizing Early Nutrition Management of Extremely and/or Very Preterm Infants
  Not yet recruiting · Interventional · 200 enrolled · Children's Hospital of Fudan University
  NCT07538999updated 2026-04-20
• Oral Carnitine in Heart Failure Patients
  Recruiting · Early phase 1 · Interventional · 20 enrolled · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
  NCT07201714updated 2026-04-20
• Expanded Access to Triheptanoin
  Available · Expanded access · Ultragenyx Pharmaceutical Inc
  NCT03773770updated 2026-04-13
• A Study to Determine the Effect of Triheptanoin Compared With Even-Chain MCT on MCEs in Pediatric Patients With LC-FAOD
  Active not recruiting · Phase 3 · Interventional · 69 enrolled · Ultragenyx Pharmaceutical Inc
  NCT05933200updated 2026-04-07

Frequently asked questions

How does Carnitine work?

Mechanism-of-action class: Biological Macromolecular Activity.

What is Carnitine used for?

According to FDA labeling, Carnitine carries indications including: Aids in mobilization of fat deposits and cellulite.† †Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Carnitine?

Carnitine is classified as Biological Macromolecular Activity.