pharmacopeia
GET
/api/v1/drug/esomeprazole
2D structure
6-methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-benzimidazole
SMILES CC1=CN=C(C(=C1OC)C)C[S@](=O)C2=NC3=C(N2)C=C(C=C3)OC
InChIKey SUBDBMMJDZJVOS-DEOSSOPVSA-N

Mechanism of action

Sourced from openFDA

Mechanism-of-action classes: Cytochrome P450 2C19 Inhibitors; Proton Pump Inhibitors.

Cytochrome P450 2C19Proton Pump

Indications

Sourced from openFDA
  • Uses • treats frequent heartburn (occurs 2 or more days a week) • not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect

Dosage & administration

Sourced from openFDA

Directions • adults 18 years of age and older • this product is to be used once a day (every 24 hours), every day for 14 days • may take 1 to 4 days for full effect 14-Day Course of Treatment • swallow 1 capsule with a glass of water before eating in the morning • take every day for 14 days • do not take more than 1 capsule a day • swallow whole. Do not crush or chew capsules. • do not use for more than 14 days unless directed by your doctor Repeated 14-Day Courses (if needed) • you may repeat a 14-day course every 4 months • do not take for more than 14 days or more often than every 4 months unless directed by a doctor • children under 18 years of age: ask a doctor before use. Heartburn in children may sometimes be caused by a serious condition.

Warnings & precautions

Sourced from openFDA

Allergy alert: • Do not use if you are allergic to esomeprazole. • Esomeprazole may cause severe skin reactions. Symptoms may include: • skin reddening • blisters • rash If an allergic reaction occurs, stop use and seek medical help right away. Do not use if you have: • trouble or pain swallowing food, vomiting with blood, or bloody or black stools • heartburn with lightheadedness, sweating or dizziness • chest pain or shoulder pain with shortness of breath; sweating; pain spreading to arms, neck or shoulders; or lightheadedness • frequent chest pain These may be signs of a serious condition. See your doctor. Ask a doctor before use if you have • had heartburn over 3 months. This may be a sign of a more serious condition. • frequent wheezing, particularly with heartburn • unexplained weight loss • nausea or vomiting • stomach pain Ask a doctor or pharmacist before use if you are • taking a prescription drug. Acid reducers may interact with certain prescription drugs. Stop use and ask a doctor if • your heartburn continues or worsens • you need to take this product for more than 14 days • you need to take more than 1 course of treatment every 4 months • you get diarrhea • you develop a rash or joint pain If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).

Approval history

Sourced from openFDA
  • Feb 20, 2001NDANDA021153Astrazeneca
  • Oct 20, 2006NDANDA021957Astrazeneca
  • Feb 27, 2008NDANDA022101Astrazeneca
  • Aug 6, 2013NDANDA202342Belcher
  • Mar 28, 2014NDANDA204655Astrazeneca Lp
  • Aug 3, 2015ANDAANDA078936Mylan
  • Sep 25, 2015ANDAANDA078279Dr Reddys
  • Nov 23, 2015NDANDA207920Astrazeneca Lp

FAERS reports

View JSON
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
233,112 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Chronic Kidney Disease35,58215%
  2. 2Acute Kidney Injury20,4448.8%
  3. 3Renal Failure16,2747.0%
  4. 4Drug Ineffective14,2856.1%
  5. 5Nausea13,4585.8%
  6. 6Gastrooesophageal Reflux Disease11,9615.1%
  7. 7Diarrhoea11,1764.8%
  8. 8Drug Dose Omission11,1264.8%
  9. 9Pain10,7104.6%
  10. 10End Stage Renal Disease10,2984.4%
  11. 11Malaise9,9774.3%
  12. 12Fatigue9,9054.2%
  13. 13Headache9,5354.1%
  14. 14Renal Injury9,5294.1%
  15. 15Off Label Use9,5144.1%

Literature

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Recent PubMed references pinned to Esomeprazole as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 564 ClinicalTrials.gov registrations naming Esomeprazole as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Pharmacogenomics

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CPIC-curated drug–gene pairs for Esomeprazole. Levels describe the strength of curated evidence and guideline status — never a recommendation to test or to adjust therapy.

Structural analogs

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Ranked by 2D fingerprint (Tanimoto) similarity over PubChem structures. Structural proximity only — not a claim of therapeutic equivalence.

Frequently asked questions

How does Esomeprazole work?
Mechanism-of-action classes: Cytochrome P450 2C19 Inhibitors; Proton Pump Inhibitors.
What is Esomeprazole used for?
According to FDA labeling, Esomeprazole carries indications including: Uses • treats frequent heartburn (occurs 2 or more days a week) • not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Esomeprazole?
Esomeprazole is classified as Proton pump inhibitors, Proton Pump Inhibitor, Cytochrome P450 2C19 Inhibitors, Proton Pump Inhibitors, Inhibition Gastric Acid Secretion.
What are the brand names for Esomeprazole?
Esomeprazole is marketed under brand names including Nexium, Vimovo.
Note. Data for esomeprazole is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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