Helium

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

• Jul 5, 2013NDANDA205767Linde North America Inc
• Jul 14, 2013NDANDA205819Norco Inc
• Jul 20, 2013NDANDA205843Airgas Usa Llc
• Jul 21, 2013NDANDA205849Praxair Inc
• Aug 2, 2013NDANDA205889Matheson Tri-gas Inc
• Aug 5, 2013NDANDA205912Praxair Distribution Inc
• Mar 4, 2014NDANDA206826Linde Gas North America Llc
• Feb 20, 2016NDANDA209033Nexair Llc

1. 1Completed Suicide2344%
2. 2Asphyxia612%
3. 3Overdose612%
4. 4Toxicity To Various Agents59.6%
5. 5Drug Ineffective47.7%
6. 6Generalised Tonic-clonic Seizure47.7%
7. 7Sedation47.7%
8. 8Drug Level Increased35.8%
9. 9Myalgia35.8%
10. 10Off Label Use35.8%
11. 11Abnormal Behaviour23.8%
12. 12Aggression23.8%
13. 13Cataplexy23.8%
14. 14Death23.8%
15. 15Depression23.8%

Recent PubMed references pinned to Helium as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Cell survival comparison of proton, helium, and carbon ion interlaced minibeams in water phantom simulations.
  Medical physics · 2026 · Rousseti A, Dollinger G, Reindl J, et al.
  PMID 42260269DOI 10.1002/mp.70516
• Time-dependent modulation of MC3T3-E1 pre-osteoblasts by a helium cold plasma: a preliminary study on its potential relevance for alveolar bone regeneration.
  Biomedical physics & engineering express · 2026 · Negrescu AM, Zampieri L, Martines E, et al.
  PMID 42208566DOI 10.1088/2057-1976/ae744b
• Extraterrestrial (3)He flux variability during the Triassic recorded in pelagic bedded cherts of Japan.
  Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2026 · Onoue T, Setoyama K, Sato H, et al.
  PMID 42108093DOI 10.2183/pjab.102.012
• Differential roles of ATM and Chk2 in cold atmospheric helium plasma-induced cell death in Molt-4 human leukemia cell with intact or reduced p53 expression.
  Biochemical and biophysical research communications · 2026 · Muratani T, Iwashima K, Sakamoto F, et al.
  PMID 42107399DOI 10.1016/j.bbrc.2026.153843
• Cryo-HIM-SIMS on the npSCOPE: Correlative Topographic, Transmitted and SIMS Imaging at Cryogenic Temperatures.
  Analytical chemistry · 2026 · Taubitz T, De Castro O, Andersen D, et al.
  PMID 42009306DOI 10.1021/acs.analchem.5c06908
• Radiobiology of Particle Therapy: Revisiting the Preclinical Knowledge Base on Helium Ion Therapy.
  Cancer journal (Sudbury, Mass.) · 2026 · Wang L, Popovtzer A, Koong AC, et al.
  PMID 41880265DOI 10.1097/PPO.0000000000000820
• Review of excursion procedures used in commercial heliox saturation diving.
  Diving and hyperbaric medicine · 2026 · Imbert JP, Matity L, Massimelli JY, et al.
  PMID 41875439DOI 10.28920/dhm56.1.21-40
• Safety and efficacy of a helium-oxygen mix for pediatric respiratory failure associated with anatomical and functional stenotic lesions of the airway: a phase II clinical trial.
  Respiratory medicine · 2026 · Morikawa Y, Morimoto K, Kodani T, et al.
  PMID 41412268DOI 10.1016/j.rmed.2025.108592

The 10 most recently updated of 117 ClinicalTrials.gov registrations naming Helium as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Study of Tolerance to the Application of Cold Plasma in the Treatment of Chronic Wounds
  Recruiting · Interventional · 40 enrolled · Centre Hospitalier Régional d'Orléans
  NCT07564739updated 2026-05-15
• Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
  Recruiting · Interventional · 78 enrolled · University of Texas Southwestern Medical Center
  NCT05723679updated 2026-05-07
• Efficacy of Combined Intravascular Laser Irradiation and Electroacupuncture on the Pain-insomnia Cycle in Chronic Sciatica: A Pilot Randomized Trial
  Completed · Interventional · 66 enrolled · Le Hoang Minh Quan
  NCT06755593updated 2026-04-23
• Evaluation of the FYNA Research OPM MEG Device for Locating Epileptic Foci as Part of Pre-surgical Assessment of Epilepsy
  Not yet recruiting · Interventional · 70 enrolled · Hospices Civils de Lyon
  NCT07281222updated 2026-04-23
• Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation
  Completed · Interventional · 12 enrolled · University of California, San Diego
  NCT06071715updated 2026-04-08
• Cold Atmospheric Plasma Device Extension Study
  Terminated · Phase 3 · Interventional · 60 enrolled · Medical University of South Carolina
  NCT05937672updated 2026-04-03
• Helium-free Magnetocardiography Guided Therapy for Stable Coronary Artery Disease - A Randomized Controlled Trial
  Recruiting · Interventional · 1,312 enrolled · Beijing Anzhen Hospital
  NCT07341932updated 2026-04-02
• Histological Evaluation of Human Skin Bx to Assess the Effects of APR Tx as an Adjunct Procedure in Facelift Surgery
  Completed · Interventional · 7 enrolled · Apyx Medical
  NCT06243744updated 2026-03-24
• Study of Airflow in the Lungs Using Helium MRI
  Completed · Interventional · 24 enrolled · University of Virginia
  NCT02154568updated 2026-03-17
• Cryoablation vs Lumpectomy in T1 Breast Cancers
  Recruiting · Interventional · 120 enrolled · Washington University School of Medicine
  NCT05505643updated 2026-02-27

Frequently asked questions

How does Helium work?

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

What class of drug is Helium?

Helium is classified as Medical gases, Unknown Cellular or Molecular Interaction, Decreased Metabolic Rate.