Generalised Tonic-clonic Seizure

22 drugs6,520 FAERS reportsMedDRA PT

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.

DefinitionNLM MeSH D012640

Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Source: U.S. National Library of Medicine — MeSH (Seizures)

Drugs reporting Generalised Tonic-clonic Seizure (22)

Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.

1Helium47.7%
2Methsuximide116.1%
3Ethosuximide1415.8%
4Relebactam55.6%
5Fenfluramine2355.4%
6Felbamate633.6%
7Bromine193.6%
8Eslicarbazepine1133.6%
9Stiripentol693.4%
10Rufinamide843.3%
11Lacosamide1,1503.2%
12Flumazenil263.1%
13Cetrorelix203.0%
14Emapalumab52.7%
15Clobazam6252.6%
16Disulfiram272.4%
17Perampanel1692.3%
18Cenobamate1852.3%
19Telisotuzumab12.2%
20Levetiracetam2,8772.2%
21Cannabidiol3671.6%
22Brivaracetam324—

Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.

Literature

Recent PubMed references pinned to Seizures as a MeSH major topic. About the reaction term itself — not about any specific drug.

Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.
Brain and behavior · 2026 · Akkol S, Brinyark HE, Chatfield R, et al.
PMID 42204888DOI 10.1002/brb3.71507
The relationship of cucurbitacin E with epileptic seizures, circadian rhythm, and genetics in a pentylenetetrazole-induced mouse model of epilepsy.
Molecular biology reports · 2026 · Sarıcı SB, Ovayolu Ö, Yılmaz ŞG, et al.
PMID 42201503DOI 10.1007/s11033-026-11973-x
Navigating diagnostic overlap between seizures and movement disorders: A practical clinical approach.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026 · Mohammed WB, Lira VST, Andrade DM, et al.
PMID 42192013DOI 10.1007/s10072-026-09127-9
[The prognosis for febrile seizures].
Ugeskrift for laeger · 2026 · Nabil D, Debes NM, Miranda MJ, et al.
PMID 42186882DOI 10.61409/V05250422
Perceptions and Emotions Toward Diets and Supplements Among Reddit Users With Functional/Dissociative Seizures and Their Caregivers: A Mixed-Methods Analysis of r/PNESsupport.
Brain and behavior · 2026 · Abbasi H, Taheri N, Jafari A, et al.
PMID 42178894DOI 10.1002/brb3.71497
Cyclic Recurrence of Seizures as a Marker for Super-Refractory Status Epilepticus.
Brain and behavior · 2026 · Le Goïc M, Chavez M, Demeret S, et al.
PMID 42178824DOI 10.1002/brb3.71396

What this is

Generalised Tonic-clonic Seizure is a MedDRA Preferred Term reported on FAERS adverse-event submissions. Each entry below is one drug from the dataset whose FAERS reports mention this reaction.

MeSH descriptor

ID: D012640
Name: Seizures
Synonyms: Seizure, Jacksonian Seizure, Seizure, Jacksonian, Single Seizure, Seizure, Single, Single Seizures, Atonic Absence Seizures, Atonic Absence Seizure, Absence Seizure, Atonic, Absence Seizures, Atonic, Seizure, Atonic Absence, Seizures, Focal, Focal Seizure, Focal Seizures, Seizure, Focal, Partial Seizures, Partial Seizure, Seizure, Partial, Seizures, Generalized, Generalized Seizure, Generalized Seizures, Seizure, Generalized, Seizures, Sensory, Seizure, Sensory, Sensory Seizure, Sensory Seizures, Seizures, Auditory, Auditory Seizure, Auditory Seizures, Seizure, Auditory, Convulsive Seizures, Seizure, Convulsive, Seizures, Convulsive, Seizures, Motor, Motor Seizure, Motor Seizures, Seizure, Motor, Convulsive Seizure, Seizures, Gustatory, Gustatory Seizure, Gustatory Seizures, Seizure, Gustatory, Seizures, Olfactory, Olfactory Seizure, Olfactory Seizures, Seizure, Olfactory, Seizures, Somatosensory, Seizure, Somatosensory, Somatosensory Seizure, Somatosensory Seizures, Seizures, Vertiginous, Seizure, Vertiginous, Vertiginous Seizure, Vertiginous Seizures, Seizures, Vestibular, Seizure, Vestibular, Vestibular Seizure, Vestibular Seizures, Seizures, Visual, Seizure, Visual, Visual Seizure, Visual Seizures, Convulsion, Non-Epileptic, Convulsion, Non Epileptic, Convulsions, Non-Epileptic, Non-Epileptic Convulsion, Non-Epileptic Convulsions, Nonepileptic Seizures, Non-Epileptic Seizures, Non Epileptic Seizures, Nonepileptic Seizure, Seizure, Nonepileptic, Seizures, Nonepileptic, Non-Epileptic Seizure, Non Epileptic Seizure, Seizure, Non-Epileptic, Complex Partial Seizures, Complex Partial Seizure, Partial Seizure, Complex, Partial Seizures, Complex, Seizure, Complex Partial, Epileptic Seizures, Seizures, Epileptic, Epileptic Seizure, Seizure, Epileptic, Generalized Absence Seizures, Generalized Absence Seizure, Absence Seizure, Generalized, Absence Seizures, Generalized, Seizure, Generalized Absence, Tonic-Clonic Seizures, Seizures, Tonic-Clonic, Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizure, Generalized Tonic Clonic Seizures, Seizure, Generalized Tonic-Clonic, Seizures, Generalized Tonic-Clonic, Tonic-Clonic Seizure, Generalized, Tonic-Clonic Seizures, Generalized, Tonic Clonic Seizure, Clonic Seizures, Tonic, Clonic Seizure, Tonic, Seizure, Tonic Clonic, Tonic Clonic Seizures, Tonic-Clonic Seizure, Seizure, Tonic-Clonic, Myoclonic Seizures, Myoclonic Seizure, Seizure, Myoclonic, Clonic Seizures, Seizures, Clonic, Clonic Seizure, Seizure, Clonic, Tonic Seizures, Seizures, Tonic, Tonic Seizure, Seizure, Tonic, Atonic Seizures, Atonic Seizure, Seizure, Atonic, Convulsions, Convulsion, Absence Seizures, Petit Mal Convulsion, Convulsion, Petit Mal, Absence Seizure, Seizure, Absence
Tree: C10.597.742, C23.888.592.742

Sits under

Neurologic Manifestations

Full MeSH record

Try the API

cURLbash

curl https://pharmacopeia.dev/api/v1/reaction/generalised-tonic-clonic-seizure

Source

Source: openFDA · FAERS
Coding: MedDRA Preferred Term
Aliases: —

open.fda.gov/data/faers/

Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.

Generalised Tonic-clonic Seizure

DefinitionNLM MeSH D012640

Drugs reporting Generalised Tonic-clonic Seizure (22)

Related reactions

Literature

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