Loratadine

Mechanism-of-action class: Histamine H1 Receptor Antagonists.

• Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: • runny nose • itchy, watery eyes • sneezing • itching of the nose or throat

Directions adults and children 6 years and over 1 tablet daily; not more than 1 tablet in 24 hours children under 6 years of age ask a doctor consumers with liver or kidney disease ask a doctor

Do not use if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use if you have liver or kidney disease. Your doctor should determine if you need a different dose. When using this product do not take more than directed. Taking more than directed may cause drowsiness. Stop use and ask a doctor if an allergic reaction to this product occurs. Seek medical help right away. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

• Apr 12, 1993NDANDA019658Bayer Healthcare Llc
• Nov 14, 1994NDANDA019670Bayer Healthcare Llc
• Aug 23, 1996NDANDA020470Bayer Healthcare Llc
• Oct 10, 1996NDANDA020641Bayer Healthcare Llc
• Dec 23, 1996NDANDA020704Bayer Healthcare Llc
• Dec 19, 2002NDANDA021375Fdn Consumer
• Aug 23, 2006NDANDA021891Bayer Healthcare Llc
• Dec 12, 2006NDANDA021993Bayer Healthcare Llc

1. 1Drug Ineffective14,52013%
2. 2Fatigue6,7616.0%
3. 3Nausea6,0295.3%
4. 4Headache5,5424.9%
5. 5Dyspnoea4,9304.4%
6. 6Diarrhoea4,9024.3%
7. 7Off Label Use4,7474.2%
8. 8Dizziness4,6254.1%
9. 9Pain4,1943.7%
10. 10Rash3,5023.1%
11. 11Pruritus3,3623.0%
12. 12Insomnia3,2572.9%
13. 13Somnolence3,2052.8%
14. 14Cough3,1322.8%
15. 15Vomiting3,0932.7%

Recent PubMed references pinned to Loratadine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Spectral residual augmented classical least squares for simultaneous green determination of cetirizine, fexofenadine and loratadine by UV spectrophotometry in pharmaceuticals and environmental samples.
  Scientific reports · 2026 · Alqahtani A, Alqahtani T, Alshehri A, et al.
  PMID 42236886DOI 10.1038/s41598-026-56246-6
• Synthesis of desloratadine analogues as potent antifungal agents: in vitro and in vivo efficacy, and structure-activity relationship studies.
  Bioorganic chemistry · 2026 · Wali S, Ghazal F, Atia-Tul-Wahab, et al.
  PMID 42013599DOI 10.1016/j.bioorg.2026.109848
• A Cu-based metal-organic framework based on desloratadine and siHIF-1α for achievement of genes/drugs/CDT combination therapy in hepatocellular carcinoma.
  Journal of nanobiotechnology · 2026 · Ding D, Huang Z, Wang L, et al.
  PMID 42010649DOI 10.1186/s12951-026-04334-0
• Orodispersible tablets as delivery platform for oral administration of drug-loaded nanoparticles to paediatric patients.
  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2026 · Cornilă A, Iurian S, Tefas LR, et al.
  PMID 41866000DOI 10.1016/j.ejpb.2026.115061
• Combinatorial Anti-Mitotic Activity of Loratadine/5-Fluorouracil Loaded Zein Tannic Acid Nanoparticles in Breast Cancer Therapy: In silico, in vitro and Cell Studies.
  International journal of nanomedicine · 2026 · Hamdi M, Al-Tabakha MM, Ali IH, et al.
  PMID 41858579DOI 10.2147/IJN.S564050
• 'Oral isotretinoin plus desloratadine for acne vulgaris: an updated global meta-analysis of efficacy, safety, and patient-centered outcomes'.
  The Journal of dermatological treatment · 2026 · Alrubaiaan MT, Bajamaan R, Altuwaijri AM, et al.
  PMID 41840862DOI 10.1080/09546634.2026.2644003
• Investigation of the impacts of second-generation antihistamines on free-living marine nematodes and their interaction with ZnS nanoparticles: Mechanistic insights from community and population approaches and molecular interactions modeling.
  Marine environmental research · 2026 · Ghannem S, Labiadh H, Ishak S, et al.
  PMID 41797016DOI 10.1016/j.marenvres.2026.107969
• Repurposing loratadine to reverse colistin resistance in Klebsiella pneumoniae through targeting lipid A modification.
  Emerging microbes & infections · 2026 · Wu X, Ge Z, Zhan H, et al.
  PMID 41678146DOI 10.1080/22221751.2026.2623697

The 10 most recently updated of 99 ClinicalTrials.gov registrations naming Loratadine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
  Recruiting · Phase 3 · Interventional · 284 enrolled · Sanofi
  NCT05263206updated 2026-06-08
• Loratadine for the Reduction of G-CSF Induced Bone Pain in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization
  Recruiting · Early phase 1 · Interventional · 70 enrolled · Rutgers, The State University of New Jersey
  NCT04211259updated 2026-05-29
• Efficacy of Auricular Acupressure Combined With Antihistamines in Patients With Wind-Heat Type Urticaria.
  Not yet recruiting · Interventional · 66 enrolled · University of Medicine and Pharmacy at Ho Chi Minh City
  NCT07575464updated 2026-05-08
• A Prospective, Single-centre, Observational Cohort Study on the Efficacy and Safety of Bacterial Lysate (OM-85) in Combination With Antihistamines for the Treatment of Chronic Spontaneous Urticaria (CSU)
  Not yet recruiting · Observational · 132 enrolled · The Fourth Affiliated Hospital of Zhejiang University School of Medicine
  NCT07557888updated 2026-05-07
• Comparison of Antihistamine and Antileukotriene Add-On Therapy to Intranasal Corticosteroid in Allergic Rhinitis
  Not yet recruiting · Phase 4 · Interventional · 32 enrolled · Liaquat National Hospital & Medical College
  NCT07532993updated 2026-04-16
• Evaluating Premedication Regimens (Methylprednisolone vs Dexamethasone-based) for the Prevention of Systemic and Injection Site Reactions to Motixafortide in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization, PARADE Trial
  Recruiting · Phase 4 · Interventional · 94 enrolled · Emory University
  NCT07101445updated 2026-02-10
• Loratadine for the Prevention of G-CSF-related Bone Pain
  Recruiting · Phase 2 · Interventional · 78 enrolled · AHS Cancer Control Alberta
  NCT05421416updated 2026-02-05
• The Effect of Apple Fruit Extract (Malus Sylvestris Mill) as an Antioxidant and Anti-Inflammatory on Allergic Rhinitis
  Completed · Interventional · 40 enrolled · Universitas Sebelas Maret
  NCT07380178updated 2026-02-02
• Comparing Diosmin-Hesperidin and Loratadine to Prevent Bone Pain From G-CSF in Patients With Blood Cancers
  Recruiting · Interventional · 88 enrolled · Alexandria University
  NCT07300735updated 2025-12-29
• Study of H3B-6545 in Japanese Women With Estrogen Receptor (ER)-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer
  Completed · Phase 1 · Interventional · 33 enrolled · Eisai Co., Ltd.
  NCT04568902updated 2025-10-23

Frequently asked questions

How does Loratadine work?

Mechanism-of-action class: Histamine H1 Receptor Antagonists.

What is Loratadine used for?

According to FDA labeling, Loratadine carries indications including: Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: • runny nose • itchy, watery eyes • sneezing • itching of the nose or throat. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Loratadine?

Loratadine is classified as Other antihistamines for systemic use, Histamine H1 Receptor Antagonists, Decreased Histamine Activity.

What are the brand names for Loratadine?

Loratadine is marketed under brand names including Alavert, Alavert D, Allerclear, Claritin, Claritin-D, Cleartime Indoor & Outdoor Allergies, Loradamed, Tavist Non-Sedating.