Neomycin

Mechanism-of-action class: Protein Synthesis Inhibitors.

• Use first aid to help prevent infection in minor scrapes, cuts, and burns

Directions clean affected area apply a small amount 1 to 3 times daily may cover with a sterile bandage

For external use only Do not use in eyes over large areas of the body or on puncture wounds, animal bites or serious burns for more than 1 week unless directed by a doctor if you are allergic to any of the ingredients Stop use and ask a doctor if a rash or allergic reaction develops condition worsens or persists Keep out of reach of children If ingested, contact a Poison Control Center right away.

• May 17, 1962NDANDA050356Ph Health
• Jun 6, 1963NDANDA050023Harrow Eye
• Jun 11, 1963ANDAANDA060700Eurofarma
• Jul 19, 1963NDANDA050065Sandoz
• Sep 2, 1964ANDAANDA060304Teva
• May 25, 1975NDANDA060613Casper Pharma Llc
• Aug 25, 1983ANDAANDA062423Sandoz
• May 22, 1984ANDAANDA062341Sandoz

1. 1Drug Ineffective91414%
2. 2Drug Hypersensitivity90014%
3. 3Pain84413%
4. 4Malaise80512%
5. 5Off Label Use78812%
6. 6Rash78012%
7. 7Vomiting75312%
8. 8Infusion Related Reaction74411%
9. 9Pyrexia72911%
10. 10Fatigue72611%
11. 11Dyspnoea71711%
12. 12Type 2 Diabetes Mellitus66910%
13. 13Nausea66810%
14. 14Swelling65010%
15. 15Systemic Lupus Erythematosus6289.7%

Recent PubMed references pinned to Neomycin as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Neomycin Exhibits Immunomodulatory and Antiviral Activity Against Influenza B Virus.
  Viruses · 2026 · Romanovskaya-Romanko E, Plotnikova M, Shurygina AP, et al.
  PMID 42043233DOI 10.3390/v18040444
• Cross-species and cross-border spread of aph(3')-ia-mediated neomycin resistance in Escherichia coli from animals: a genomic perspective.
  The Journal of antimicrobial chemotherapy · 2026 · Pirolo M, Abuoun M, Duggett N, et al.
  PMID 41995000DOI 10.1093/jac/dkag143
• Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide.
  Food research international (Ottawa, Ont.) · 2026 · Cai J, Huang A, You L, et al.
  PMID 41794459DOI 10.1016/j.foodres.2026.118574
• Targeting the LPS-STING axis: neomycin restores STING-mediated anti-tumor immune suppression and inhibits tumor growth.
  Frontiers in immunology · 2025 · Fan H, Fu D, Tian M, et al.
  PMID 41235258DOI 10.3389/fimmu.2025.1637667
• Spatial Distribution and Temporal Dynamics of Neomycin-Induced Neuromast Cell Damage and Regeneration in the Mexican tetra (Astyanax mexicanus).
  Cells · 2025 · Goel G, Sanghai N, Tranmer GK, et al.
  PMID 41227325DOI 10.3390/cells14211680
• The aphA1 kanamycin and neomycin resistance gene originated in Klebsiella michiganensis.
  The Journal of antimicrobial chemotherapy · 2025 · Moran RA, Hall RM
  PMID 41041972DOI 10.1093/jac/dkaf372
• Highly sensitive fluorescence turn-on detection of neomycin utilizing premicellar surfactant aggregation in dye-surfactant assembly.
  Analytica chimica acta · 2025 · Mishra N, Chittela RK, Chakraborty G, et al.
  PMID 41022502DOI 10.1016/j.aca.2025.344565
• Surface-Enhanced Raman Spectroscopy (SERS) Method for Rapid Detection of Neomycin and Chloramphenicol Residues in Chicken Meat.
  Sensors (Basel, Switzerland) · 2025 · Wu Y, Huang J, Tong N, et al.
  PMID 40648178DOI 10.3390/s25133920

The 10 most recently updated of 78 ClinicalTrials.gov registrations naming Neomycin as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders
  Active not recruiting · Phase 2 · Interventional · 15 enrolled · M.D. Anderson Cancer Center
  NCT04729322updated 2026-06-12
• Precision Alemtuzumab Dosing for Allogeneic Hematopoietic Cell Transplantation
  Recruiting · Phase 2 · Interventional · 60 enrolled · Children's Hospital Medical Center, Cincinnati
  NCT05501756updated 2026-06-12
• Analysis of MicroBial Metabolites After Eating Refined Food
  Completed · Interventional · 46 enrolled · The Cleveland Clinic
  NCT04308473updated 2026-05-11
• Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure
  Recruiting · Phase 1 · Interventional · 40 enrolled · Melana Yuzefpolskaya, MD
  NCT07490054updated 2026-05-05
• Multi-omics Dissection of Gut Microbiome Engraftment During FMT
  Not yet recruiting · Interventional · 90 enrolled · Catholic University of the Sacred Heart
  NCT06992453updated 2026-04-28
• Sebum Metabolomics and Lipidomics for Clinical Applications
  Not yet recruiting · Interventional · 200 enrolled · National Taiwan University Hospital
  NCT07549828updated 2026-04-24
• Intestinal Microbiome Transplant in ALS
  Recruiting · Phase 1 · Phase 2 · Interventional · 20 enrolled · Duke University
  NCT07017946updated 2026-04-13
• CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease
  Active not recruiting · Early phase 1 · Interventional · 100 enrolled · The Cleveland Clinic
  NCT01731236updated 2026-03-23
• Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery
  Active not recruiting · Phase 4 · Interventional · 630 enrolled · Ottawa Hospital Research Institute
  NCT03663504updated 2026-01-30
• Do Topical Antibiotics Improve Skin Graft Results?
  Completed · Observational · 142 enrolled · LAMB Project
  NCT07286851updated 2025-12-16

CPIC-curated drug–gene pairs for Neomycin. Levels describe the strength of curated evidence and guideline status — never a recommendation to test or to adjust therapy.

• MT-RNR1CPIC AClinPGx 1AFDA label: Actionable PGx
  MT-RNR1 and Aminoglycosides

Frequently asked questions

How does Neomycin work?

Mechanism-of-action class: Protein Synthesis Inhibitors.

What is Neomycin used for?

According to FDA labeling, Neomycin carries indications including: Use first aid to help prevent infection in minor scrapes, cuts, and burns. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Neomycin?

Neomycin is classified as Antibiotics, Antiinfectives, Antiinfectives and antiseptics for local oral treatment, Other aminoglycosides, Other antibiotics for topical use, Aminoglycoside Antibacterial, Protein Synthesis Inhibitors, Decreased Protein Synthesis.

What are the brand names for Neomycin?

Neomycin is marketed under brand names including Cortisporin, Cortisporin-TC, Cuadriderma, Lanabiotic, Maxitrol, Mycitracin Plus Pain Reliever, Neo-Polycin, Neo-Polycin HC.