Nitrous Oxide
GET
/api/v1/drug/nitrous-oxideMechanism of action
Sourced from openFDAMechanism-of-action class: Nitric Oxide Donors.
Approval history
Sourced from openFDA- Jun 16, 2013NDANDA205704Air Liquide America Speciality Gases
- Sep 3, 2013NDANDA206009Nitrous Oxide Corp
- Sep 6, 2013NDANDA206014Nitrous Oxide Of Canada
- Jan 9, 2017NDANDA209989Matheson Tri-gas Inc
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
2,152 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Drug Abuse1356.3%
- 2Drug Interaction1336.2%
- 3Cardiac Arrest1215.6%
- 4Anaesthetic Complication Neurological1175.4%
- 5Bradycardia1014.7%
- 6Hypotension944.4%
- 7Subacute Combined Cord Degeneration843.9%
- 8Toxicity To Various Agents813.8%
- 9Off Label Use673.1%
- 10Drug Ineffective653.0%
- 11Hyperthermia Malignant532.5%
- 12Paraesthesia502.3%
- 13Vomiting492.3%
- 14Drug Dependence482.2%
- 15Substance Use472.2%
Literature
Recent PubMed references pinned to Nitrous Oxide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Analgesic effect of premixed nitrous oxide in postoperative rehabilitation for ankle fractures: a randomized controlled trial.Annals of medicine · 2026 · Qiu X, Wang F, Wang Y, et al.PMID 42268729DOI 10.1080/07853890.2026.2685317
- [Effects of Microplastic Input on N(2)O Production and Pathways in Rice-wheat Rotational Cropland Soils in Subtropical Hilly Areas].Huan jing ke xue= Huanjing kexue · 2026 · Wang LS, Luo DW, Wang QM, et al.PMID 42191629DOI 10.13227/j.hjkx.202504038
- Sediment physicochemical and dissolved organic matter control microbial responses and nitrous oxide emissions across a coastal wetland transition from invasion to reclamation.Journal of environmental management · 2026 · Cao S, Liu Y, Yang P, et al.PMID 42184766DOI 10.1016/j.jenvman.2026.130020
- Warming and N addition amplify alpine peatland N(2)O emissions via divergent microbial and nutrient pathways.Journal of environmental management · 2026 · Liu X, Liu Y, Wang C, et al.PMID 42172848DOI 10.1016/j.jenvman.2026.129951
- Differential patterns and controls of N(2)O emission from coastal rivers with varying land uses and salinity in northern China.Journal of environmental management · 2026 · Yang F, Zhong J, Wang S, et al.PMID 42143425DOI 10.1016/j.jenvman.2026.129899
- Effect of excess and restricted inorganic carbon on biokinetics, nitrous oxide emissions, and microbial community in a full-nitrification bioreactor.Environmental research · 2026 · Heo S, Jeon JH, Lee S, et al.PMID 42142565DOI 10.1016/j.envres.2026.124726
- Underestimation of Future Agricultural Soil N(2)O Emissions and Abatement Needs.Global change biology · 2026 · Lu C, Li L, Winiwarter W, et al.PMID 42138433DOI 10.1111/gcb.70919
- Paphia undulata enhances sedimentary CH(4) and N(2)O emissions via divergent microbial mechanisms.Marine environmental research · 2026 · Zhong Z, Ruan Y, Qian J, et al.PMID 42134209DOI 10.1016/j.marenvres.2026.108103
Clinical trials
The 10 most recently updated of 353 ClinicalTrials.gov registrations naming Nitrous Oxide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE)Active not recruiting · Interventional · 70 enrolled · University of North Carolina, Chapel HillNCT03554356updated 2026-06-08
- Comparative Clinical Study Between Virtual Reality Hypnosis and Nitrous Oxide Inhalation for Dental AnxieTerminated · Interventional · 30 enrolled · University Hospital, Strasbourg, FranceNCT05167331updated 2026-06-08
- Evaluating the Impact of Cryo-analgesia on Recovery After Double Lung TransplantationRecruiting · Interventional · 40 enrolled · University Hospital, GasthuisbergNCT06959056updated 2026-06-05
- Nitrous Oxide NeuroimagingRecruiting · Early phase 1 · Interventional · 60 enrolled · Keith M VogtNCT06702631updated 2026-06-04
- Evaluation of Botulinum TOXin Type A in the Treatment of Buerger's DiseaseNot yet recruiting · Phase 3 · Interventional · 8 enrolled · University Hospital, ToulouseNCT05698979updated 2026-06-01
- Neurological Impairment in a Young Population Exposed to Recreational Nitrous OxideTerminated · Observational · 20 enrolled · Centre Hospitalier Universitaire de NīmesNCT05469321updated 2026-06-01
- The 50:50 Nitrous Oxide vs 2% Lidocaine ChallengeRecruiting · Interventional · 62 enrolled · Institute for Oncology and Radiology of SerbiaNCT07618676updated 2026-06-01
- C2 CryoBalloon™ 180 Ablation System Dose De-escalation Study.Active not recruiting · Interventional · 62 enrolled · Merit Medical Systems, Inc.NCT03311451updated 2026-05-22
- Biological Diagnosis and Monitoring of Chronic Nitrous Oxide AbuseRecruiting · Observational · 356 enrolled · University Hospital, LilleNCT05540561updated 2026-05-19
- Virtual Reality in Pediatric DentistryCompleted · Interventional · 20 enrolled · University of Southern CaliforniaNCT05585905updated 2026-05-18
Frequently asked questions
- How does Nitrous Oxide work?
- Mechanism-of-action class: Nitric Oxide Donors.
- What class of drug is Nitrous Oxide?
- Nitrous Oxide is classified as Other general anesthetics, Nitric Oxide Donors, Vasodilation.
Note. Data for
nitrous-oxide is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.