Oxyquinoline

Mechanism-of-action class: Chelating Activity.

W ARNING: Chemicals in various preparations can interact with the pessary material resulting in discoloration or deterioration of the pessary. TRIMO-SAN does not have a deleterious effect on any Milex pessary. Testing should be performed before using any other vaginal preparation with a pessary unless specifically prescribed by your healthcare professional.

TRIMO-SAN and PREGNANCY TRIMO-SAN has NOT been tested for use during pregnancy. CooperSurgical does not recommend the use of TRIMO-SAN during pregnancy. If you wish to become pregnant, do not use TRIMO-SAN or any other personal hygiene product vaginally (douches, vaginal sprays, jellies or suppositories), for 6 hours prior to or following intercourse. Any product used within this time period could interfere with conception.

• Dec 24, 1985NDANDA019044Ge Healthcare
• Jul 25, 2018ANDAANDA202586Bwxt Itg

1. 1Death411%
2. 2Dyspnoea411%
3. 3Fatigue411%
4. 4Hot Flush37.9%
5. 5Off Label Use37.9%
6. 6Urinary Tract Infection37.9%
7. 7Abdominal Pain25.3%
8. 8Acute Kidney Injury25.3%
9. 9Arthralgia25.3%
10. 10Chills25.3%
11. 11Decreased Appetite25.3%
12. 12Diarrhoea25.3%
13. 13Drug Ineffective25.3%
14. 14Heart Rate Increased25.3%
15. 15Inappropriate Schedule Of Product Administration25.3%

Recent PubMed references pinned to Oxyquinoline as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Newly identified antimicrobial activity of an 8-hydroxyquinoline-based ionophore against multidrug-resistant Enterococcus faecium and Staphylococcus aureus.
  The Journal of antimicrobial chemotherapy · 2026 · Li G, El-Deeb IM, Whyte HG, et al.
  PMID 42235930DOI 10.1093/jac/dkag186
• Clioquinol improves Sepsis-induced immunosuppression and enhances host anti-infective defense by restoring macrophage phagocytic function.
  International immunopharmacology · 2026 · Guo B, Wang C, Chen L, et al.
  PMID 42155394DOI 10.1016/j.intimp.2026.116893
• Metal-coordination-driven self-assembly of 8-hydroxyquinoline-peptide into hybrid nanomaterials for in vitro multimodal synergistic anticancer activity.
  Organic & biomolecular chemistry · 2026 · Wang S, Tian X, Li X, et al.
  PMID 42132574DOI 10.1039/d6ob00498a
• A covalent organic framework nano-chelator orchestrates multitarget clearance of Alzheimer's pathologies.
  Journal of colloid and interface science · 2026 · Bai X, Wei Y, Zhao D, et al.
  PMID 41950681DOI 10.1016/j.jcis.2026.140451
• Light- and copper-activated (photo)cytotoxicity of 8-hydroxyquinoline-based boron photosensitizers with lipid droplet targeting and lipid peroxidation accumulation.
  Dalton transactions (Cambridge, England : 2003) · 2026 · Pham TC, Kim G, Thong PV, et al.
  PMID 41504480DOI 10.1039/d5dt01016k
• Bifunctional BODIPY-Clioquinol Copper Chelator with Multiple Anti-AD Properties.
  International journal of molecular sciences · 2025 · Abramchuk DS, Krasnovskaya OO, Voskresenskaya AS, et al.
  PMID 41465301DOI 10.3390/ijms262411876
• Exploring Ga(3+) metal complexes of a tryptophan metabolite in microbiota exposed to ionizing radiation.
  Bioorganic chemistry · 2026 · Monteiro B, Ribeiro N, Cabo Verde S, et al.
  PMID 41435779DOI 10.1016/j.bioorg.2025.109401
• Copper(II) and zinc(II) complexes of dimeric 8-hydroxyquinoline ligands: Synthesis, metal speciation, and biological evaluation.
  Journal of inorganic biochemistry · 2026 · Panebianco R, Santonoceta GDG, Borrelli R, et al.
  PMID 41205299DOI 10.1016/j.jinorgbio.2025.113138

The 10 most recently updated of 10 ClinicalTrials.gov registrations naming Oxyquinoline as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.
  Suspended · Phase 1 · Interventional · 120 enrolled · University of Alabama at Birmingham
  NCT03807973updated 2026-06-02
• A Study of [89Zr]-Oxine-NCR100 Injection for the Cellular Distribution
  Not yet recruiting · Phase 1 · Interventional · 6 enrolled · Nuwacell Biotechnologies Co., Ltd.
  NCT07139431updated 2025-08-24
• 89Zr-Oxine-RY_SW01 Cell Injection for the Treatment of Systemic Sclerosis
  Not yet recruiting · Phase 1 · Interventional · 8 enrolled · Jiangsu Renocell Biotech Company
  NCT06489652updated 2024-07-08
• Add-on Clioquinol in Drug-resistant Childhood Epilepsy: an Exploratory Study
  Unknown · Phase 2 · Interventional · 10 enrolled · KU Leuven
  NCT05727943updated 2023-02-14
• Assessing the Efficacy of CREWS01 to Decrease Usage of Rescue Inhalers in Moderate to Severe Asthmatic Adults
  Unknown · Phase 2 · Interventional · 50 enrolled · Global United Pharmaceutical Corporation
  NCT02153541updated 2023-02-08
• Imaging Tumor-infiltrating T-cells in Non-small Cell Lung Cancer
  Completed · Phase 2 · Interventional · 20 enrolled · Radboud University Medical Center
  NCT03853187updated 2022-12-07
• Study to Evaluate the Safety of Sebryl® and Sebryl Plus® in Seborrheic Dermatitis and Psoriasis of Scalp
  Completed · Observational · 90 enrolled · Laboratorios Silanes S.A. de C.V.
  NCT05105139updated 2022-04-13
• Effectiveness of Polymyxin B Sulphate + Prednisolone + Benzocaine + Clioquinol in Acute and Sub-acute Dermatitis Eczematous
  Completed · Phase 3 · Interventional · 76 enrolled · EMS
  NCT01429701updated 2021-02-24
• Magen Haim Project - Assessing Hand Hygiene Formulas
  Unknown · Phase 4 · Interventional · 1,505 enrolled · Sheba Medical Center
  NCT03188549updated 2017-10-17
• Study Evaluating the Tolerance and Biological Activity of Oral Clioquinol in Patients With Relapsed or Refractory Hematological Malignancy
  Terminated · Phase 1 · Interventional · 11 enrolled · University Health Network, Toronto
  NCT00963495updated 2015-06-22

Frequently asked questions

How does Oxyquinoline work?

Mechanism-of-action class: Chelating Activity.

What class of drug is Oxyquinoline?

Oxyquinoline is classified as Antiinfectives and antiseptics for local oral treatment, Antiseptics, Quinoline derivatives, Chelating Activity, Unknown Physiological Effect.

What are the brand names for Oxyquinoline?

Oxyquinoline is marketed under brand names including Fem pH, Relagard, Trimo San.