Povidone-iodine
GET
/api/v1/drug/povidone-iodineMechanism of action
Sourced from openFDAMechanism-of-action class: Unknown Cellular or Molecular Interaction.
Indications
Sourced from openFDA- Uses First aid to help prevent infection in minor cuts scrapes burns
Dosage & administration
Sourced from openFDADirections clean the affected area spray a small amount of the product on the area 1 to 3 times daily may be covered with a sterile bandage if bandaged, let dry first
Warnings & precautions
Sourced from openFDAFor external use only
Approval history
Sourced from openFDA- Dec 17, 1986NDANDA018634Alcon Pharms Ltd
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
4,084 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Off Label Use46611%
- 2Endophthalmitis42210%
- 3Drug Hypersensitivity3689.0%
- 4Toxic Anterior Segment Syndrome2826.9%
- 5Rash2546.2%
- 6Drug Ineffective2305.6%
- 7Nausea2225.4%
- 8Pain2055.0%
- 9Eye Pain1994.9%
- 10Visual Acuity Reduced1654.0%
- 11Vision Blurred1624.0%
- 12Hypersensitivity1573.8%
- 13Product Use In Unapproved Indication1553.8%
- 14Dyspnoea1473.6%
- 15Diarrhoea1363.3%
Literature
Recent PubMed references pinned to Povidone-iodine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- The effect of povidone-iodine-enhanced rectal enema on procedure-related infectious complications before transrectal ultrasound-guided prostate biopsy: A prospective randomized study.Medicine · 2026 · Doğan M, Aydin C, Ekici M, et al.PMID 42152336DOI 10.1097/MD.0000000000048830
- Chlorhexidine-Alcohol Versus Povidone-Iodine for Surgical Site Infection Prevention in Abdominal Surgery in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.World journal of surgery · 2026 · Turyagumanawe J, Mukiibi E, Kakooza J, et al.PMID 42115142DOI 10.1002/wjs.70409
- Comparison of preoperative 5% povidone-iodine plus moxifloxacin versus 5% povidone-iodine alone on ocular surface bacterial flora: protocol for a randomized controlled trial.BMC ophthalmology · 2026 · Ugalahi MO, Makanjuola OB, Adebusoye SO, et al.PMID 42087126DOI 10.1186/s12886-026-04881-y
- Effectiveness of Biodress versus both honey and povidone-iodine ointment in acute wound healing in Enugu State, Nigeria: a randomised controlled trial.Journal of wound care · 2026 · Anetekhai CJ, Anarado AN, Anetekhai WI, et al.PMID 42068250DOI 10.12968/jowc.2023.0159
- Paediatric Strabismus Surgery: a Retrospective Analysis of Different Postoperative Treatment Regimes to Prevent Infections.Klinische Monatsblatter fur Augenheilkunde · 2026 · Missu M, Felber D, Palmowski-Wolfe A, et al.PMID 42008993DOI 10.1055/a-2801-0735
- Adjunctive povidone-iodine for Acanthamoeba keratitis: a randomized trial.Antimicrobial agents and chemotherapy · 2026 · Rajaraman R, Kassaye I, Sharma SS, et al.PMID 41914638DOI 10.1128/aac.01512-25
- A case report of post-traumatic eczema of the breast mimicking breast cancer: A diagnostic challenge.Medicine · 2026 · Yao M, Li Z, Liu A, et al.PMID 41861228DOI 10.1097/MD.0000000000048158
- The Patient Experience: 5% Povidone-Iodine vs 0.05% Aqueous Chlorhexidine.Ophthalmic surgery, lasers & imaging retina · 2026 · Bates B, Wood E, Storey P, et al.PMID 41818451DOI 10.3928/23258160-20260123-02
Clinical trials
The 10 most recently updated of 519 ClinicalTrials.gov registrations naming Povidone-iodine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- A Trial to Study the Influence of Ultrasound Guidance on the Complications of Central CatheterTerminated · Interventional · 264 enrolled · Centre Hospitalier Universitaire, AmiensNCT01154465updated 2026-06-12
- Efficacy of Transversus Abdominis Plane Block in Alleviating Acute AppendicitisCompleted · Interventional · 105 enrolled · Ankara City Hospital BilkentNCT06808737updated 2026-06-04
- Comprasion of SPSIP and Rhomboid Intercostal Plan Blocks on VATSRecruiting · Interventional · 40 enrolled · Cumhuriyet UniversityNCT07524673updated 2026-06-03
- Evaluating XPERIENCE™ Advanced Surgical IrrigationRecruiting · Interventional · 7,600 enrolled · Ottawa Hospital Research InstituteNCT05543941updated 2026-05-28
- Infection Prophylaxis in Total Joint ReplacementRecruiting · Phase 3 · Interventional · 21,006 enrolled · Hamilton Health Sciences CorporationNCT06126614updated 2026-05-22
- A Pilot Study Efficiency of Techniques of 'Snail ' and 'Go-back' Application of an Alcoholic Antiseptic on Healthy Skin Before the Placement of a Intra-vascular Device,Completed · Interventional · 132 enrolled · University Hospital, BordeauxNCT04002245updated 2026-05-14
- Suprascapular Nerve PRF for Central Sensitization and Neuropathic PainActive not recruiting · Observational · 60 enrolled · Gülçin BabaoğluNCT06857409updated 2026-05-08
- Parasitic Ulcer Treatment Trial PilotCompleted · Phase 2 · Interventional · 49 enrolled · University of California, San FranciscoNCT03484507updated 2026-05-07
- Comparison of the Effects of Local Anesthetic Infiltration and Erector Spinae Plan (ESP) Block on Postoperative Recovery Quality and Pain in Lumbar Spinal SurgeryCompleted · Interventional · 80 enrolled · Aydin Adnan Menderes UniversityNCT07065006updated 2026-05-06
- Effectiveness of Platelet-rich Plasma Treatment of Knee OsteoarthritisActive not recruiting · Phase 2 · Interventional · 110 enrolled · Universidad Nacional de Entre RiosNCT05825105updated 2026-05-06
Frequently asked questions
- How does Povidone-iodine work?
- Mechanism-of-action class: Unknown Cellular or Molecular Interaction.
- What is Povidone-iodine used for?
- According to FDA labeling, Povidone-iodine carries indications including: Uses First aid to help prevent infection in minor cuts scrapes burns. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Povidone-iodine?
- Povidone-iodine is classified as Antiseptics, Iodine products, Medicated dressings with antiinfectives, Medicated shampoos, Other antiinfectives, Other antiinfectives and antiseptics, Antiseptic, Unknown Cellular or Molecular Interaction, Unknown Physiological Effect.
- What are the brand names for Povidone-iodine?
- Povidone-iodine is marketed under brand names including Betadine, Clinidine, Dermawound, Efodine, Ovadine, Summer's Eve Medicated.
Note. Data for
povidone-iodine is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.