Rutin

• For the temporary relief of sinus or nasal congestion, hay fever, minor joint pain, or irritability due to sensitivity to phenolic compounds found in foods or other products.*

DIRECTIONS Place drops under tongue 30 minutes before/after meals. Adults and children 12 years and over: Take 10 drops up to 3 times per day. Consult a physician for use in children under 12 years of age.

In case of overdose, get medical help or contact a poison control center right away. Keep out of the reach of children. If pregnant or breastfeeding, ask a healthcare professional before use.

1. 1Pain1012%
2. 2Dizziness78.6%
3. 3Fatigue78.6%
4. 4Arthralgia67.4%
5. 5Oedema Peripheral56.2%
6. 6Acute Kidney Injury44.9%
7. 7Asthenia44.9%
8. 8Dyspnoea44.9%
9. 9Eye Pain44.9%
10. 10Headache44.9%
11. 11Heart Rate Increased44.9%
12. 12Hyperhidrosis44.9%
13. 13Hypoaesthesia44.9%
14. 14Insomnia44.9%
15. 15Joint Swelling44.9%

Recent PubMed references pinned to Rutin as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Mechanistic approach on the protective role of rutin against ammonia-induced hepatic encephalopathy in Nile tilapia (Oreochromis niloticus) focusing on Cox-2/NF-κB pathway.
  Fish physiology and biochemistry · 2026 · Mohamed WA, Hassanen EI, Khalefa HS, et al.
  PMID 42234204DOI 10.1007/s10695-026-01711-2
• Evaluation of Ultrasonic-Assisted Aqueous Two-Phase Extraction of Rutin from the Leaves of Moringa oleifera Lam. Through Response Surface Methodology.
  Advances in experimental medicine and biology · 2026 · Ndou DL, Ndhlala AR, Tavengwa NT, et al.
  PMID 42213320DOI 10.1007/978-3-032-24254-9_2
• Rutin enhances the analgesic efficacy of low-dose pregabalin without sedative side effects in a rat model of chronic constriction injury.
  The Journal of pharmacy and pharmacology · 2026 · Helvacı G, Arslan R, Bektaş N, et al.
  PMID 42166536DOI 10.1093/jpp/rgag054
• Rutin Protects Ischemic Stroke-Induced Astrocytic Injury by Activating PRDX1.
  Biological & pharmaceutical bulletin · 2026 · Said A, Liu S, Cao R, et al.
  PMID 42161532DOI 10.1248/bpb.b25-00790
• Dietary rutin enhances growth performance and antioxidant defense under ammonia stress in Nile tilapia (Oreochromis Niloticus).
  Veterinary research communications · 2026 · Mohamed WA, Hassanen EI, Khalefa HS, et al.
  PMID 42133139DOI 10.1007/s11259-026-11246-9
• Antibacterial activity and mechanism of rutin in UV‑A light treatment against Escherichia coli O157:H7.
  Archives of microbiology · 2026 · Wang J, Zhu Y, Liu T, et al.
  PMID 42126426DOI 10.1007/s00203-026-04946-y
• Troxerutin attenuates paclitaxel-induced cardiotoxicity through modulation of ferroptosis and GRP78/ATF6/CHOP signaling in rats.
  European journal of pharmacology · 2026 · El-Naggar YM, El Wakeel S, George MY, et al.
  PMID 42103053DOI 10.1016/j.ejphar.2026.178944
• Therapeutic effect of rutin on Henoch-Schönlein purpura by attenuating inflammation and protection of the intestinal barrier function in rats.
  European journal of pharmacology · 2026 · Zhao W, Ouyang M, Mu J, et al.
  PMID 42103052DOI 10.1016/j.ejphar.2026.178946

The 10 most recently updated of 57 ClinicalTrials.gov registrations naming Rutin as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Inhibition of HBV Replication and Biological Reversal of Cirrhosis (F3-F4) and HCC by Flavonoids
  Completed · Phase 4 · Interventional · 134 enrolled · Trieu, Nguyen Thi, M.D.
  NCT07084948updated 2026-06-05
• The Effect of a Peer-Based Instructional Disaster Education Program on Disaster Preparedness Beliefs and Disaster Attitudes of First Aid and Emergency Program Students
  Enrolling by invitation · Interventional · 75 enrolled · Selcuk University
  NCT07564999updated 2026-05-27
• The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain
  Completed · Interventional · 124 enrolled · Cairo University
  NCT06298383updated 2026-05-20
• TIME MANAGEMENT DURING HAEMODIALYSIS ON ANXIETY AND FEAR IN CHILDREN
  Completed · Interventional · 20 enrolled · Istanbul University - Cerrahpasa
  NCT07593001updated 2026-05-18
• Effects of Rutin on Oxidative Stress, Inflammatory Markers, and Blood Flow Velocity During Cycling 40km Time Trial Performance
  Completed · Interventional · 12 enrolled · China Medical University Hospital
  NCT07518355updated 2026-04-08
• Breathing Exercises for Pain and Anxiety During Arteriovenous Fistula Cannulation
  Completed · Interventional · 90 enrolled · Emine Kaplan Serin
  NCT07427875updated 2026-04-07
• Nursing Education Provided After Cesarean Section Surgery.
  Enrolling by invitation · Interventional · 80 enrolled · Namik Kemal University
  NCT07467304updated 2026-03-12
• Comfort Communication Model Intervention for Burn Pain and Pain Anxiety
  Not yet recruiting · Interventional · 62 enrolled · Baskent University
  NCT07385339updated 2026-03-02
• Evaluation of Digital Decision-support Tool for Child Nutritional Monitoring: a Protocol for Cluster Randomized Controlled Trial in Urban and Semi-Urban Areas in Indonesia
  Active not recruiting · Interventional · 1,030 enrolled · Center for Indonesia's Strategic Development Initiatives
  NCT07027384updated 2026-02-23
• Effects of Body Mechanics Training on Shoulder-Back Pain and Breastfeeding Ergonomics in Breastfeeding Mothers
  Active not recruiting · Interventional · 94 enrolled · Ege University
  NCT07104227updated 2026-02-20

Frequently asked questions

What is Rutin used for?

According to FDA labeling, Rutin carries indications including: For the temporary relief of sinus or nasal congestion, hay fever, minor joint pain, or irritability due to sensitivity to phenolic compounds found in foods or other products.*. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Rutin?

Rutin is classified as Bioflavonoids.