Serotonin

• USES: Temporarily eases low serotonin symptoms such as - Stress-Anxiety - Depression - Overactivity - Sleeplessness Serotonin is a neurotransmitter that keeps us calm, relaxed, and in control. Serotonin is found in the brain and throughout the body.

DIRECTIONS: Adults: Take 15 drops under the tounge as needed up to six times a day or as directed by a health care professional. Children: Take 5 drops per pounds of body weight or as directed by a health care professional.

Do not use with SSRIs, SSNIs, MAOs, or TCA (tricyclic anti-depressants). If pregnant or lactating, consult your health care professional before use. KEEP OUT OF THE REACH OF CHILDREN. DO NOT expose to heat. Store tightly closed in a cool, dry place. Safety Sealed for your protection and product freshness. Do not use if safety seal is broken or missing. In case of overdose, get medical help or contact a Posion Control Center right away.

1. 1Drug Interaction9020%
2. 2Suicide Attempt8619%
3. 3Acute Kidney Injury8418%
4. 4Intentional Overdose8017%
5. 5Major Depression8017%
6. 6Metabolic Acidosis8017%
7. 7Physical Deconditioning8017%
8. 8Serotonin Syndrome8017%
9. 9Drug Exposure During Pregnancy4610%
10. 10Nausea316.8%
11. 11Diarrhoea214.6%
12. 12Pain214.6%
13. 13Vomiting214.6%
14. 14Fatigue204.4%
15. 15Drug Abuse194.1%

Recent PubMed references pinned to Serotonin as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Circadian-Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3-NO Pathway.
  Journal of pineal research · 2026 · Qiu S, Cai S, Xie R, et al.
  PMID 42262169DOI 10.1111/jpi.70154
• Precise and simultaneous SERS detection of sertraline and serotonin on large-scale sub-20 nm plasmonic gold nanocone arrays.
  Mikrochimica acta · 2026 · Gajdošová K, Bui TL, Chaloupková Z, et al.
  PMID 42249219DOI 10.1007/s00604-026-08164-7
• Machine Learning-assisted Raman Spectral Analysis of Serotonin-responsive ssDNA-SWCNT Nanosensor for Improved Selectivity against Dopamine.
  Journal of visualized experiments : JoVE · 2026 · Choe Y, Park M, Jeong S, et al.
  PMID 42224224DOI 10.3791/69925
• Modulation of the Mechanosensory Matrisome by Serotonergic Signaling.
  Results and problems in cell differentiation · 2026 · Uray IP, Ramirez SC, Uray KL, et al.
  PMID 42223642DOI 10.1007/978-3-032-19509-8_11
• 5-Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis.
  CNS neuroscience & therapeutics · 2026 · Zhou L, Li M, Dai Q, et al.
  PMID 42212756DOI 10.1002/cns.70946
• Gut Microbiota-Mediated Modulation of Intestinal Serotonin by Tea Polyphenols: Potential Mechanisms and Implications for Metabolic Health.
  Nutrients · 2026 · Jiang L, Yu Y, Zheng M, et al.
  PMID 42197066DOI 10.3390/nu18101606
• Multi-Omics Integrated Analysis Reveals Correlative Signatures of Short-Chain PFAS Mixtures on Mouse Midbrain Dopaminergic Neurons Involving the TM/5-HT Pathway.
  International journal of molecular sciences · 2026 · Sun T, Yang M, Ma Y, et al.
  PMID 42196519DOI 10.3390/ijms27104543
• Efavirenz-Altered Gut-Microbiota, Tph1, and Systemic 5-HT Levels: Could They Affect Depression Mechanisms in Mice?
  International journal of molecular sciences · 2026 · Rojas-Osornio SA, Paredes-Cervantes V, Aguirre-García MM, et al.
  PMID 42196482DOI 10.3390/ijms27104504

The 10 most recently updated of 829 ClinicalTrials.gov registrations naming Serotonin as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)
  Recruiting · Phase 1 · Phase 2 · Interventional · 170 enrolled · Merck Sharp & Dohme LLC
  NCT07227597updated 2026-06-12
• A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults
  Recruiting · Phase 1 · Interventional · 18 enrolled · Otsuka Pharmaceutical Development & Commercialization, Inc.
  NCT07329621updated 2026-06-12
• ACP-204 in Adults With Alzheimer's Disease Psychosis
  Recruiting · Phase 2 · Phase 3 · Interventional · 1,074 enrolled · ACADIA Pharmaceuticals Inc.
  NCT06159673updated 2026-06-12
• A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)
  Recruiting · Phase 1 · Phase 2 · Interventional · 460 enrolled · Merck Sharp & Dohme LLC
  NCT06843447updated 2026-06-12
• Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery
  Completed · Interventional · 40 enrolled · Plovdiv Medical University
  NCT07644065updated 2026-06-12
• Serotonin Variants & Gut Microbiota in Mental Health
  Not yet recruiting · Observational · 30 enrolled · Neurobiologix
  NCT07634458updated 2026-06-10
• sElective Serotonin reuPtake inhibitoRs In posT-covid After COVID-19
  Recruiting · Phase 3 · Interventional · 160 enrolled · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
  NCT07359482updated 2026-06-09
• A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD
  Active not recruiting · Phase 4 · Interventional · 304 enrolled · University of Pennsylvania
  NCT04961190updated 2026-06-09
• Integrating a Stepped Care Model of Screening and Treatment for Depression Into Malawi's National HIV Care Delivery Platform
  Completed · Phase 4 · Interventional · 487 enrolled · RAND
  NCT04777006updated 2026-06-09
• Natural History of Familial Carcinoid Tumor
  Recruiting · Observational · 1,600 enrolled · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  NCT00646022updated 2026-06-08

Frequently asked questions

What is Serotonin used for?

According to FDA labeling, Serotonin carries indications including: USES: Temporarily eases low serotonin symptoms such as - Stress-Anxiety - Depression - Overactivity - Sleeplessness Serotonin is a neurotransmitter that keeps us calm, relaxed, and in control. Serotonin is found in the brain and throughout the body.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.