Hypothyroidism
19 drugs9,340 FAERS reportsMedDRA PT
GET
/api/v1/reaction/hypothyroidismReference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.
DefinitionNLM MeSH D007037
A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
Source: U.S. National Library of Medicine — MeSH (Hypothyroidism)
Drugs reporting Hypothyroidism (19)
Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.
- 1Sodium Iodide40236%
- 2Penpulimab617%
- 3Bexarotene755.8%
- 4Liothyronine4295.0%
- 5Penicillin V1154.7%
- 6Lenvatinib1,0523.3%
- 7Pembrolizumab2,7992.8%
- 8Atezolizumab1,0272.7%
- 9Dostarlimab512.5%
- 10Propylthiouracil472.3%
- 11Nivolumab2,0662.2%
- 12Avelumab862.2%
- 13Ethiodized Oil252.0%
- 14Ipilimumab8242.0%
- 15Cemiplimab311.6%
- 16Relatlimab71.6%
- 17Durvalumab2861.5%
- 18Gallium61.4%
- 19Gozetotide61.4%
Related reactions
Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.
- Colitis8 shared · 0.25
- Pneumonitis8 shared · 0.22
- Myocarditis3 shared · 0.15
- Interstitial Lung Disease6 shared · 0.12
- Cerebral Amyloid Angiopathy2 shared · 0.11
- Pathological Fracture2 shared · 0.11
- Maternal Exposure Before Pregnancy2 shared · 0.10
- Amylase Increased2 shared · 0.10
- Lipase Increased2 shared · 0.10
- Positron Emission Tomogram Abnormal2 shared · 0.10
Literature
Recent PubMed references pinned to Hypothyroidism as a MeSH major topic. About the reaction term itself — not about any specific drug.
- Maternal exposure to the thyroperoxidase-inhibiting pesticide amitrole induces hypothyroidism and developmental neurotoxicity in the rat brain.Frontiers in endocrinology · 2026 · Ramhøj L, Ardenkjær-Skinnerup J, Davidsen N, et al.PMID 42205262DOI 10.3389/fendo.2026.1823237
- Levothyroxine Treatment During Pregnancy: A Metabolomics Study.Basic & clinical pharmacology & toxicology · 2026 · Kärkkäinen O, Sahlman H, Keski-Nisula L, et al.PMID 42171403DOI 10.1111/bcpt.70246
- [Analysis of influencing factors and construction of a predictive model for permanent congenital hypothyroidism in neonates with congenital hypothyroidism].Zhonghua yi xue za zhi · 2026 · Luo CW, Zhu XY, Li XL, et al.PMID 42161614DOI 10.3760/cma.j.cn112137-20251202-03155
- Unveiling the clinical connections between vitamin B12 deficiency anemia, Hashimoto thyroiditis, and hypothyroidism: New insights from Mendelian randomization studies.Medicine · 2026 · Chen L, Huang W, Zhang J, et al.PMID 42152417DOI 10.1097/MD.0000000000048901
- Third-trimester estradiol is associated with isolated maternal hypothyroxinemia and attenuated TSH-FT4 coupling: evidence from rats and human astrocytes.Frontiers in endocrinology · 2026 · Xu Y, Wang Z, Cai Q, et al.PMID 42147109DOI 10.3389/fendo.2026.1795855
- Association between hypothyroidism, levothyroxine replacement and kidney function outcomes: a systematic review and meta-analysis.Frontiers in endocrinology · 2026 · Wang X, Shang X, Li Y, et al.PMID 42147108DOI 10.3389/fendo.2026.1841255
Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.