Lithium
/api/v1/drug/lithiumMechanism of action
Sourced from openFDAMechanism-of-action classes: Norepinephrine Transporter Interactions; Serotonin Transporter Interactions.
Indications
Sourced from openFDA- Uses: Use the leaflet enclosed for detail.
Dosage & administration
Sourced from openFDAFor best results, do this: Take 3-5 tablets 3-4 times a day. If you weigh less than 100 lbs, use half a dose or take it as prescribed. Contraindications: Traditional Homeopathic formulations do not interact with other remedies, herbs, or other supplements.
Warnings & precautions
Sourced from openFDAand Storage: Ask a professional before use if pregnant or breast feeding or if you have severe symptoms. Keep away from children. If you have a reaction to this product that is not positive, discontinue use. Store in a cool and dry place. Packaging: 30gm jar standard quality packing.
Approval history
Sourced from openFDA- Apr 27, 1979NDANDA018027Ani Pharms
- Nov 26, 1980NDANDA017812Hikma
- Jan 29, 1982NDANDA018558Hikma
- May 21, 1986ANDAANDA070755Pai Holdings Pharm
- Jan 5, 2004ANDAANDA076691Hikma
- Oct 28, 2004ANDAANDA076832Hikma
- Jan 12, 2009ANDAANDA079159Alembic Ltd
- Feb 3, 2009ANDAANDA079139Glenmark Pharms Ltd
FAERS reports
- 1Toxicity To Various Agents3,3818.1%
- 2Drug Ineffective3,3448.0%
- 3Tremor2,5666.1%
- 4Drug Interaction2,5346.1%
- 5Nausea2,2055.3%
- 6Off Label Use2,1325.1%
- 7Weight Increased1,9334.6%
- 8Fatigue1,7834.3%
- 9Depression1,7204.1%
- 10Vomiting1,7064.1%
- 11Insomnia1,6273.9%
- 12Anxiety1,5913.8%
- 13Somnolence1,5453.7%
- 14Confusional State1,4623.5%
- 15Dizziness1,4193.4%
Literature
Recent PubMed references pinned to Lithium as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- An integrated method for state of charge estimation, lifetime prediction, and reliability assessment of Lithium-ion batteries under thermal and dynamic conditions.PloS one · 2026 · Mobasheri P, Aranizadeh A, Vahidi B, et al.PMID 42224246DOI 10.1371/journal.pone.0343872
- Effect of the PPARγ Agonist Pioglitazone on Rat Behavior and Expression of Epileptogenesis-Related Genes during the Latent Phase of the Lithium-Pilocarpine Model.Biochemistry. Biokhimiia · 2026 · Kharisova AR, Zubareva OE, Kovalenko AA, et al.PMID 42219391DOI 10.1134/S0006297926600183
- Comprehensive and high-efficiency leaching process for achieving full-component recovery of spent lithium iron phosphate cathode powder.Waste management (New York, N.Y.) · 2026 · Yang Z, Wu M, Chen Y, et al.PMID 42202432DOI 10.1016/j.wasman.2026.115608
- Targeting Mitochondrial Dysfunction in Alzheimer's Disease Neurons: Lithium Boosts Oxidative Phosphorylation.Cells · 2026 · Albensi BC, Adlimoghaddam APMID 42193907DOI 10.3390/cells15100896
- Enrichment of lithium by lithium-accumulating bacteria and its enhancement by electrical stimulation.Bioresource technology · 2026 · Chen Y, Han X, Shen Y, et al.PMID 42173374DOI 10.1016/j.biortech.2026.134950
- Physiological regulation and threshold behavior of lithium uptake and removal by perennial ryegrass.Ecotoxicology and environmental safety · 2026 · Zhang Y, Chen N, Zu B, et al.PMID 42161112DOI 10.1016/j.ecoenv.2026.120292
- Kidney Transplantation for Lithium Nephrotoxicity is Associated With Noninferior Graft and Patient Survival: A National Donor-Stratified Registry Analysis.Clinical transplantation · 2026 · Cohen H, Toro D, Zuluaga D, et al.PMID 42138931DOI 10.1111/ctr.70563
- A Comprehensive Analytical Procedure and Environmental Behavior of Lithium-Ion Battery-Related Fluorinated Anions and Ultrashort-Chain PFAS.Environmental science & technology · 2026 · Shi Z, Zhu F, Liu F, et al.PMID 42138715DOI 10.1021/acs.est.5c17568
Clinical trials
The 10 most recently updated of 452 ClinicalTrials.gov registrations naming Lithium as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Studies of Brain Function and Course of Illness in Pediatric Bipolar DisorderRecruiting · Observational · 2,350 enrolled · National Institute of Mental Health (NIMH)NCT00025935updated 2026-06-12
- A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or LamotrigineRecruiting · Phase 3 · Interventional · 424 enrolled · Bristol-Myers SquibbNCT07140913updated 2026-06-10
- Baseline Assessment of Skin Resident Memory T Cells in Healthy Unvaccinated ParticipantsNot yet recruiting · Interventional · 40 enrolled · Institute of Tropical Medicine, BelgiumNCT07636551updated 2026-06-09
- Pharmacokinetic Study of Pembrolizumab and Its Impact on Immunity and the Tumor Microenvironment, Which May Explain the Efficacy of Post-immunotherapy Chemotherapy.Not yet recruiting · Phase 4 · Interventional · 110 enrolled · Centre Antoine LacassagneNCT07633613updated 2026-06-08
- LiO-AD: Lithium Orotate in Alzheimers Disease Feasibility, Biomarker Engagement, and Clinical ResponseNot yet recruiting · Phase 1 · Phase 2 · Interventional · 40 enrolled · Johns Hopkins UniversityNCT07459959updated 2026-06-08
- C-TST for Diagnosis of Latent Mycobacterium Tuberculosis Infection in IndonesiaCompleted · Interventional · 300 enrolled · Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.NCT07587164updated 2026-06-03
- A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)Recruiting · Phase 3 · Interventional · 450 enrolled · Bristol-Myers SquibbNCT06929273updated 2026-06-02
- A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant InpatientsRecruiting · Interventional · 396 enrolled · University of GreifswaldNCT04996433updated 2026-05-26
- Validation of the French Version of the Lithium Knowledge Test (LKT)Terminated · Observational · 22 enrolled · University Hospital, LilleNCT06033326updated 2026-05-22
- A Study Evaluating 24 Months of Lithium Carbonate Treatment in Patients With TBR1-related Neurocognitive DisorderRecruiting · Phase 1 · Phase 2 · Interventional · 12 enrolled · Centre Hospitalier Universitaire DijonNCT06776848updated 2026-05-22
Frequently asked questions
- How does Lithium work?
- Mechanism-of-action classes: Norepinephrine Transporter Interactions; Serotonin Transporter Interactions.
- What is Lithium used for?
- According to FDA labeling, Lithium carries indications including: Uses: Use the leaflet enclosed for detail.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Lithium?
- Lithium is classified as Lithium, Norepinephrine Transporter Interactions, Serotonin Transporter Interactions, Norepinephrine Activity Alteration, Serotonin Activity Alteration.
lithium is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.