Hepatic Encephalopathy
6 drugs818 FAERS reportsMedDRA PT
GET
/api/v1/reaction/hepatic-encephalopathyReference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.
DefinitionNLM MeSH D006501
A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum and Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
Source: U.S. National Library of Medicine — MeSH (Hepatic Encephalopathy)
Drugs reporting Hepatic Encephalopathy (6)
Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.
- 1Becaplermin1100%
- 2Moxidectin133%
- 3Terlipressin165.6%
- 4Rifaximin7903.9%
- 5Acamprosate92.9%
- 6Lusutrombopag12.6%
Related reactions
Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.
- Hepatic Failure3 shared · 0.20
- Hepatic Cirrhosis2 shared · 0.18
- Ammonia Increased2 shared · 0.17
- Liver Disorder2 shared · 0.10
- Ascites3 shared · 0.06
- Blood Glucose Increased2 shared · 0.03
- Pancytopenia2 shared · 0.02
- Overdose2 shared · 0.02
- Hospitalisation2 shared · 0.02
- Toxicity To Various Agents2 shared · 0.01
Literature
Recent PubMed references pinned to Hepatic Encephalopathy as a MeSH major topic. About the reaction term itself — not about any specific drug.
- Zinc deficiency and sarcopenia define a metabolic frailty phenotype predicting hepatic encephalopathy and early mortality in cirrhosis.Metabolic brain disease · 2026 · Méndez-Guerrero O, Carranza-Carrasco A, Guerrero-Guerrero R, et al.PMID 42207388DOI 10.1007/s11011-026-01879-9
- Clinical Challenges in the Management of Hepatic Encephalopathy in Older Patients with Cirrhosis: A Nationwide Italian Physician-Reported Survey.Medicina (Kaunas, Lithuania) · 2026 · Lapenna L, Di Cola S, Nardelli S, et al.PMID 42195208DOI 10.3390/medicina62050955
- Optimal Timing of Therapeutic Plasma Exchange and Hepatic Encephalopathy Severity as Predictors of Clinical Outcome in Liver Failure: A Retrospective Observational Study.Journal of clinical apheresis · 2026 · Charmode JS, Das S, Aishwarya V, et al.PMID 42120342DOI 10.1002/jca.70131
- Choroid plexus cyst burden is associated with glymphatic dysfunction and cognitive impairment in hepatic encephalopathy.Hepatology communications · 2026 · Chen L, Zhang Z, Fang J, et al.PMID 42118981DOI 10.1097/HC9.0000000000000950
- Covert hepatic encephalopathy in cirrhosis: implications for early diagnosis and appropriate management.Clinical journal of gastroenterology · 2026 · Saeki C, Toyonaga T, Torisu Y, et al.PMID 42081077DOI 10.1007/s12328-026-02354-9
- Central Administration of Recombinant IGF1 Is Neuroprotective in a Rodent Model of Acute Liver Failure.International journal of molecular sciences · 2026 · Wang Y, McMillin M, Frampton G, et al.PMID 42074188DOI 10.3390/ijms27083547
Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.