Irritability
14 drugs4,564 FAERS reportsMedDRA PT
GET
/api/v1/reaction/irritabilityReference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.
DefinitionNLM MeSH D007508
Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience.
Source: U.S. National Library of Medicine — MeSH (Irritable Mood)
Drugs reporting Irritability (14)
Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.
- 1Trifluoperazine3831%
- 2Serdexmethylphenidate385.4%
- 3Helium23.8%
- 4Viloxazine373.8%
- 5Perampanel2423.3%
- 6Dexmethylphenidate1553.2%
- 7Varenicline2,2342.7%
- 8Cerliponase132.6%
- 9Vortioxetine4182.5%
- 10Onasemnogene Abeparvovec562.5%
- 11Lisdexamfetamine8242.4%
- 12Bazedoxifene212.3%
- 13Vigabatrin2781.9%
- 14Brivaracetam208—
Related reactions
Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.
- Anger4 shared · 0.22
- Disturbance In Attention4 shared · 0.19
- Aggression7 shared · 0.16
- Suicidal Ideation8 shared · 0.12
- Abnormal Behaviour3 shared · 0.10
- Generalised Tonic-clonic Seizure3 shared · 0.09
- Multiple-drug Resistance2 shared · 0.08
- Epilepsy3 shared · 0.08
- Product Availability Issue2 shared · 0.07
- Status Epilepticus2 shared · 0.07
Literature
Recent PubMed references pinned to Irritable Mood as a MeSH major topic. About the reaction term itself — not about any specific drug.
- Emotion Regulation Treatment for Irritability and Disruptive Behavior: A Preliminary Investigation.Behavior therapy · 2026 · Turner KA, White BA, Ollendick TH, et al.PMID 42097789DOI 10.1016/j.beth.2025.09.009
- Affective Temperament Traits as Predictors of Menopausal Symptom Severity in the Late Menopausal Transition and Early Postmenopause.The journal of obstetrics and gynaecology research · 2026 · Hayırlıoğlu N, İlhan CPMID 42091421DOI 10.1111/jog.70317
- 'It's more than just irritability': perspectives and experiences of irritability among people affected by Huntington's disease.Psychology & health · 2026 · Tindall T, Dale M, Simpson J, et al.PMID 42026825DOI 10.1080/08870446.2025.2474010
- Understanding tonic and phasic irritability in developmental psychopathology among help-seeking children and adolescents in Switzerland: Protocol for the longitudinal multimodal UTOPICA study.BMJ open · 2026 · Urben S, Giovannini J, Dietsche A, et al.PMID 42020130DOI 10.1136/bmjopen-2025-111168
- Pain and irritability in Pediatric ileocolic and small bowel intussusception: A comparative study.The American journal of emergency medicine · 2026 · Shlomovitz Y, Brooks R, Rekhtman D, et al.PMID 41720039DOI 10.1016/j.ajem.2026.02.017
- Interaction Effects of Irritability and Anhedonia on ERP and Time-Frequency Measures of Reward Sensitivity.Psychophysiology · 2026 · Bellaert N, Cassioli F, Crowley MJ, et al.PMID 41715986DOI 10.1111/psyp.70260
Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.