Epilepsy
27 drugs17,982 FAERS reportsMedDRA PT
GET
/api/v1/reaction/epilepsyReference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. The drugs below are ranked by how often this reaction appears on FAERS reports for each drug — high share does not mean the drug caused the reaction, and absence from this list does not mean the reaction never occurred. This is not a symptom checker.
DefinitionNLM MeSH D004827
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Drugs reporting Epilepsy (27)
Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.
- 1Ceftobiprole716%
- 2Dextran 40913%
- 3Levomilnacipran1598.5%
- 4Botulinum Toxin Type A8086.8%
- 5Afamelanotide15.3%
- 6Perampanel3404.6%
- 7Relebactam44.5%
- 8Ethosuximide1064.3%
- 9Valproate8324.1%
- 10Miglustat443.9%
- 11Stiripentol793.9%
- 12Lacosamide1,3683.8%
- 13Clobazam8253.5%
- 14Rufinamide793.1%
- 15Levetiracetam4,0463.1%
- 16Carbamazepine2,0053.0%
- 17Felbamate492.8%
- 18Oxcarbazepine8972.8%
- 19Phenobarbital4312.8%
- 20Zonisamide3872.7%
- 21Lamotrigine3,2942.5%
- 22Valproic Acid6552.1%
- 23Vigabatrin2992.1%
- 24Phenytoin8162.0%
- 25Cilastatin751.8%
- 26Imipenem751.8%
- 27Brivaracetam292—
Related reactions
Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.
- Convulsion17 shared · 0.40
- Status Epilepticus12 shared · 0.38
- Multiple-drug Resistance8 shared · 0.26
- Generalised Tonic-clonic Seizure10 shared · 0.26
- Seizure20 shared · 0.19
- Aggression8 shared · 0.14
- Irritability3 shared · 0.08
- Somnolence18 shared · 0.07
- Blepharospasm2 shared · 0.07
- Pathogen Resistance3 shared · 0.06
Literature
Recent PubMed references pinned to Epilepsy as a MeSH major topic. About the reaction term itself — not about any specific drug.
- Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.Brain and behavior · 2026 · Akkol S, Brinyark HE, Chatfield R, et al.PMID 42204888DOI 10.1002/brb3.71507
- Efficacy of Levetiracetam in Patients With Pediatric Epilepsy: A Systematic Review and Meta-Analysis.Neurology · 2026 · Balestrini S, Puliti D, Lombardini M, et al.PMID 42202238DOI 10.1212/WNL.0000000000218080
- The relationship of cucurbitacin E with epileptic seizures, circadian rhythm, and genetics in a pentylenetetrazole-induced mouse model of epilepsy.Molecular biology reports · 2026 · Sarıcı SB, Ovayolu Ö, Yılmaz ŞG, et al.PMID 42201503DOI 10.1007/s11033-026-11973-x
- Uncovering the Key Circuit FOSL2/FOS/EGR3/EGR1, Contributing to the Hyperexcitability of Excitatory Neurons in the Epileptic Temporal Cortex and Hippocampus.International journal of molecular sciences · 2026 · Chen J, Zhao B, Yang K, et al.PMID 42196443DOI 10.3390/ijms27104466
- Identification and Functional Characterization of a Novel De Novo SATB1 Frameshift Variant in a Patient with Epilepsy-Dominant Neurodevelopmental Disorders.Genes · 2026 · Xu M, Zhang R, Fan S, et al.PMID 42195022DOI 10.3390/genes17050565
- Inverse Correlation Between Nesfatin-1 and Ghrelin O-Acyltransferase (GOAT) in Adolescents with Epilepsy: A Cross-Sectional Study.Biomolecules · 2026 · Sojka A, Yetkin O, Bartosik Y, et al.PMID 42194009DOI 10.3390/biom16050658
Note. FAERS reports are voluntarily submitted and are NOT incidence rates, signals, or causal evidence. Counts reflect reporting volume, not how often a reaction occurs. Reference statistics only.