Status Epilepticus

DefinitionNLM MeSH D013226

A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)

Source: U.S. National Library of Medicine — MeSH (Status Epilepticus)

Drugs reporting Status Epilepticus (17)

Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.

1. 1Fosphenytoin1566.2%
2. 2Perampanel3254.4%
3. 3Isoflurane814.2%
4. 4Ethosuximide963.9%
5. 5Stiripentol763.7%
6. 6Potassium Bromide313.7%
7. 7Lacosamide1,2393.4%
8. 8Phenobarbital5103.3%
9. 9Pentobarbital33.3%
10. 10Clobazam7163.0%
11. 11Rufinamide642.5%
12. 12Phenytoin1,0022.5%
13. 13Midazolam6972.4%
14. 14Valproic Acid7482.4%
15. 15Levetiracetam2,8622.2%
16. 16Zonisamide3062.1%
17. 17Vigabatrin2641.8%

Related reactions

Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.

• Epilepsy12 shared · 0.38
• Multiple-drug Resistance7 shared · 0.32
• Convulsion10 shared · 0.26
• Generalised Tonic-clonic Seizure7 shared · 0.22
• Seizure16 shared · 0.16
• Aggression7 shared · 0.15
• Stevens-johnson Syndrome2 shared · 0.07
• Irritability2 shared · 0.07
• Metabolic Acidosis2 shared · 0.06
• Somnolence14 shared · 0.06

Literature

Recent PubMed references pinned to Status Epilepticus as a MeSH major topic. About the reaction term itself — not about any specific drug.

• Cyclic Recurrence of Seizures as a Marker for Super-Refractory Status Epilepticus.
  Brain and behavior · 2026 · Le Goïc M, Chavez M, Demeret S, et al.
  PMID 42178824DOI 10.1002/brb3.71396
• Reducing Time to Seizure Treatment in a Pediatric Intensive Care Unit Through Quality Improvement Methodology: Seizure to Rescue.
  Neurology. Clinical practice · 2026 · Ortman C, Bala TR, Riviello JJ, et al.
  PMID 42155074DOI 10.1212/CPJ.0000000000200622
• Neuroimmunomodulation of AMPA Receptors Through Combination of Medium-Chain Triglycerides and Perampanel to Treat Status Epilepticus in Anti-NMDA Receptor Encephalitis.
  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026 · Stadler LM, Schappe L, Lochner P, et al.
  PMID 42154348DOI 10.1007/s11481-026-10295-w
• Predictive value of frontal alpha asymmetry in evaluating prognosis of pediatric status epilepticus based on EEG assessment.
  Medicine · 2026 · Xie L, Yu T, Zhou J, et al.
  PMID 42152338DOI 10.1097/MD.0000000000048417
• Temporal Trends and Regional Variations in Mortality of Adults With Status Epilepticus in the United States: A Retrospective Study From 1999 to 2020.
  Neurology · 2026 · Nadeem ZA, Kashif MAB, Nadeem A, et al.
  PMID 42060883DOI 10.1212/WNL.0000000000214939
• EEG in nonconvulsive status epilepticus: The influence of clinical information.
  Neurologia · 2026 · Horrillo-Maysonnial A, Echeveste B, Iriarte J, et al.
  PMID 42044940DOI 10.1016/j.nrleng.2026.501938