Anhedonia

DefinitionNLM MeSH D059445

Inability to experience pleasure due to impairment or dysfunction of normal psychological and neurobiological mechanisms. It is a symptom of many PSYCHOTIC DISORDERS (e.g., DEPRESSIVE DISORDER, MAJOR; and SCHIZOPHRENIA).

Source: U.S. National Library of Medicine — MeSH (Anhedonia)

Drugs reporting Anhedonia (42)

Share = reports listing this reaction ÷ total matched reports for the drug. — means the upstream totals query failed at ingest and the denominator is unknown.

1. 1Bacillus Firmus1100%
2. 2Cystine133%
3. 3Vitamin B6120%
4. 4Gadoxetate7417%
5. 5Elvitegravir2,51416%
6. 6Cobicistat3,01915%
7. 7Lutein514%
8. 8Pantothenate513%
9. 9Tenofovir Alafenamide4,73311%
10. 10Nitroprusside4111%
11. 11Nelfinavir21010%
12. 12Tenofovir Disoproxil7,00710.0%
13. 13Emtricitabine7,3629.5%
14. 14Podofilox109.2%
15. 15Tenofovir7,6668.2%
16. 16Dolutegravir1,5788.2%
17. 17Resorcinol17.7%
18. 18Rilpivirine1,8027.4%
19. 19Gadodiamide2236.7%
20. 20Mannitol3136.5%
21. 21Gadoteridol1126.4%
22. 22Darunavir1,1205.9%
23. 23Doravirine605.9%
24. 24Abacavir9225.8%
25. 25Ferric Carboxymaltose2545.6%
26. 26Crofelemer125.2%
27. 27Etomidate1125.2%
28. 28Etravirine2195.0%
29. 29Isoflurane934.9%
30. 30Levomefolate844.4%
31. 31Drospirenone2,2864.4%
32. 32Raltegravir7084.3%
33. 33Atazanavir6014.2%
34. 34Vecuronium614.0%
35. 35Lopinavir5103.8%
36. 36Zidovudine7023.5%
37. 37Lamivudine1,4403.1%
38. 38Maraviroc622.7%
39. 39Permethrin392.3%
40. 40Sinecatechins11.9%
41. 41Ritonavir1,4631.6%
42. 42Bictegravir2,154—

Related reactions

Other reactions most often co-reported on the same drug set. Ranked by Jaccard similarity over drug-id sets — pure data-derived co-occurrence, not a clinical relationship.

• Emotional Distress38 shared · 0.52
• Osteoporosis20 shared · 0.43
• Bone Density Decreased15 shared · 0.33
• Economic Problem15 shared · 0.31
• Renal Injury13 shared · 0.25
• Osteopenia10 shared · 0.22
• Bone Loss9 shared · 0.21
• Multiple Fractures9 shared · 0.21
• Renal Impairment20 shared · 0.21
• Osteonecrosis10 shared · 0.21

Literature

Recent PubMed references pinned to Anhedonia as a MeSH major topic. About the reaction term itself — not about any specific drug.

• Chronic Mild Unpredictable Stress Selectively Downregulates Exon I Bdnf mRNA in the Rat Frontal Cortex Independently of Anhedonia.
  Cell biochemistry and function · 2026 · Stepanichev M, Peregud D, Manolova A, et al.
  PMID 42117204DOI 10.1002/cbf.70225
• Characterization of male and female rats' responses to social isolation and unpredictable stress: Motivational and hedonic effects.
  Behavioural brain research · 2026 · Vidal-de la O YB, Torres-Carrillo P, Valencia-Flores KB, et al.
  PMID 42107781DOI 10.1016/j.bbr.2026.116264
• The association between anhedonia and obesity: A systematic review.
  Psychiatry research · 2026 · Hajje N, Kwan ATH, Teopiz KM, et al.
  PMID 42061315DOI 10.1016/j.psychres.2026.117192
• Medication status is associated with metabotropic glutamate receptor 5 availability in bipolar disorder and with measures of attention, anhedonia, and cognition.
  Journal of affective disorders · 2026 · Moisieienko K, Asch RH, Davis MT, et al.
  PMID 42055136DOI 10.1016/j.jad.2026.121888
• Running Exercise Promotes Astrocyte-Mediated Structural Plasticity in the Amygdalar BLA and CeA to Alleviate Anhedonia-like Behavior Alterations.
  Cells · 2026 · Ren X, Luo Y, Xiao Q, et al.
  PMID 42041561DOI 10.3390/cells15080693
• From Neural Circuits to Behavior: Examining the Central Role of Anhedonia in Major Depression.
  Advances in experimental medicine and biology · 2026 · Ghanayem LK, Kumar P, Rizvi SJ, et al.
  PMID 42036565DOI 10.1007/978-981-95-6872-7_8